Emergence in France of multiple clones of clinical Streptococcus pneumoniae isolates with high-level resistance to amoxicillin
The genetic relatedness of French isolates of Streptococcus pneumoniae highly resistant to amoxicillin (MIC, >/=4 microg/ml, equal to or exceeding those of penicillin) was investigated by molecular fingerprinting. The results suggest that high-level resistance to amoxicillin has emerged within pr...
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| Veröffentlicht in: | Antimicrobial agents and chemotherapy 1999-06, Vol.43 (6), p.1480-1483 |
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| container_end_page | 1483 |
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| container_issue | 6 |
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| container_title | Antimicrobial agents and chemotherapy |
| container_volume | 43 |
| creator | DOIT, C LOUKIL, C FITOUSSI, F GESLIN, P BINGEN, E |
| description | The genetic relatedness of French isolates of Streptococcus pneumoniae highly resistant to amoxicillin (MIC, >/=4 microg/ml, equal to or exceeding those of penicillin) was investigated by molecular fingerprinting. The results suggest that high-level resistance to amoxicillin has emerged within preexisting penicillin-resistant clones. |
| doi_str_mv | 10.1128/AAC.43.6.1480 |
| format | Article |
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Drug treatments</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Serotyping</subject><subject>Streptococcus pneumoniae</subject><subject>Streptococcus pneumoniae - classification</subject><subject>Streptococcus pneumoniae - drug effects</subject><subject>Streptococcus pneumoniae - genetics</subject><issn>0066-4804</issn><issn>1098-6596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFvFCEUh4nR2G316NVwMN5mhYEBJvGy2bTVpEkP1TNhmTe7GGYYgal68W-X6W60nnri8d73foF8CL2hZE1prT5sNts1Z2uxplyRZ2hFSasq0bTiOVoRIkRV2vwMnaf0jZR705KX6IwSxpWUzQr9vhwg7mG0gN2Ir6JZqtDjYfbZTR6w9WGEtLSsd6OzxuO7HGHKwQZr54SnEeYhjM6UhBS8yYX-4fIBH9z-UHm4B48jJJfyQ3YO2Azhp7POl7xX6EVvfILXp_MCfb26_LL9VN3cXn_ebm4qy4XIVU2I3DGpetqqjkCraiONIpI3qq6t4V3DoG87YiTfcS6pYIxY1smai07UXLEL9PGYO827AToLY47G6ym6wcRfOhin_5-M7qD34V6rlhFa1t-f1mP4PkPKenDJgvdmhDAnLVqplKzFkyCVdSOY4AWsjqCNIaUI_d-3UKIXsbqI1ZxpoRexhX_7-AOP6KPJArw7ASYVSf1i0qV_nCINE4L9AbpzrYw</recordid><startdate>19990601</startdate><enddate>19990601</enddate><creator>DOIT, C</creator><creator>LOUKIL, C</creator><creator>FITOUSSI, F</creator><creator>GESLIN, P</creator><creator>BINGEN, E</creator><general>American Society for Microbiology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19990601</creationdate><title>Emergence in France of multiple clones of clinical Streptococcus pneumoniae isolates with high-level resistance to amoxicillin</title><author>DOIT, C ; LOUKIL, C ; FITOUSSI, F ; GESLIN, P ; BINGEN, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-2007b378f198d0e982a7a80745822ca4d53ef9d0a74b44716330c3d7246d62483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Amoxicillin - pharmacology</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>DNA Fingerprinting</topic><topic>Humans</topic><topic>Mechanisms of Resistance</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Penicillin Resistance</topic><topic>Penicillins - pharmacology</topic><topic>Pharmacology. 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| identifier | ISSN: 0066-4804 |
| ispartof | Antimicrobial agents and chemotherapy, 1999-06, Vol.43 (6), p.1480-1483 |
| issn | 0066-4804 1098-6596 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_89301 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Amoxicillin - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences DNA Fingerprinting Humans Mechanisms of Resistance Medical sciences Microbial Sensitivity Tests Penicillin Resistance Penicillins - pharmacology Pharmacology. Drug treatments Polymorphism, Restriction Fragment Length Serotyping Streptococcus pneumoniae Streptococcus pneumoniae - classification Streptococcus pneumoniae - drug effects Streptococcus pneumoniae - genetics |
| title | Emergence in France of multiple clones of clinical Streptococcus pneumoniae isolates with high-level resistance to amoxicillin |
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