Emergence in France of multiple clones of clinical Streptococcus pneumoniae isolates with high-level resistance to amoxicillin

The genetic relatedness of French isolates of Streptococcus pneumoniae highly resistant to amoxicillin (MIC, >/=4 microg/ml, equal to or exceeding those of penicillin) was investigated by molecular fingerprinting. The results suggest that high-level resistance to amoxicillin has emerged within pr...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 1999-06, Vol.43 (6), p.1480-1483
Hauptverfasser:	DOIT, C, LOUKIL, C, FITOUSSI, F, GESLIN, P, BINGEN, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amoxicillin - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences DNA Fingerprinting Humans Mechanisms of Resistance Medical sciences Microbial Sensitivity Tests Penicillin Resistance Penicillins - pharmacology Pharmacology. Drug treatments Polymorphism, Restriction Fragment Length Serotyping Streptococcus pneumoniae Streptococcus pneumoniae - classification Streptococcus pneumoniae - drug effects Streptococcus pneumoniae - genetics
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Zusammenfassung:	The genetic relatedness of French isolates of Streptococcus pneumoniae highly resistant to amoxicillin (MIC, >/=4 microg/ml, equal to or exceeding those of penicillin) was investigated by molecular fingerprinting. The results suggest that high-level resistance to amoxicillin has emerged within preexisting penicillin-resistant clones.
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.43.6.1480