Kidney Disease, Hypertension Treatment, and Cerebral Perfusion and Structure

The safety of intensive blood pressure (BP) targets is controversial for persons with chronic kidney disease (CKD). We studied the effects of hypertension treatment on cerebral perfusion and structure in individuals with and without CKD. Neuroimaging substudy of a randomized trial. A subset of parti...

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Veröffentlicht in:American journal of kidney diseases 2022-05, Vol.79 (5), p.677-687.e1
Hauptverfasser: Gaussoin, Sarah, Kendrick, Jessica, Ryan, Laurie, Vitolins, Mara, Perdue, Letitia, Lovato, James, Russell, Greg, Cloud, Loretta, Cook, Delilah, Puccinelli-Ortega, Nicole, Russell, Laurie, Warren, Stuart, Zhang, Zhu-Ming, Keasler, Lisa, Taylor, Tonya, Doshi, Jimit, Colman, Martha, Payne, Stacey, Drawz, Paul, Sedor, John R., Horwitz, Edward J., Schellling, Jeffrey R., Dobre, Mirela, Williams, Monique, Baxter, Jody, Taylor, Sara, Quinn, Sally B., He, Jiang, Krousel-Wood, Marie, Muery, Susan, Trapani, Donnalee, Diamond, Matt, Hodges, Marcela, Weathers, Charlene, McWilliams, Andrew, Everett, Kelly, Pedley, Carolyn, Zurek, Geraldine, Smoak, Mary Martha, Gordon, Lindsay, Han, Yoosun, Blackshear, Joseph, Palaj, Arta, Pemu, Priscilla, Akpalu, Derrick, Cheung, Alfred K., Beddhu, Srinivasan, Gren, Lisa, Dhar, Ritesh, Chisum, Ben, Tamura, Manju, Erickson, Kevin, Telminova, Ekaterina, Weiner, Daniel E., Sarnak, Mark, Unruh, Mark, Hess, Rachel, Thomas, Holly, Fazio, Pam, Klixbull, Elle, Komlos-Weimer, Melissa, Toto, Robert, Wang, Nancy, Wing, Maria, Goldenstein, Leonard, Thomas, Brenda, Rastogi, Anjay, Wada, Lauren, Taylor, Corliss E., Segal, Mark S., Blaum, Caroline, Nyquist, Linda, Rizik, Dana, Medina, Julia, Mack, Catherine, Womack, Catherine, Towers, Chelsea, Colon, Ilma, Carrasquillo-Navarro, Orlando J., Claudio, Jamie, Heres, Lourdes, Hu, Paula, Squindo, Erin, Flessner, Michael, Venegas, Reiner, Bello, Natalie, Homma, Shunichi, Alvarez, Julissa, Pisoni, Roberto, Hunt, Vickie, Sayers, Jessica, Swartz, Stephen, Miller, Carol, Zheng-Phelan, Ling, Mehta, Smita, Thompson, Cathy, Dixon, Troy, Amodeo, Susan, Bansal, Shweta, Dunnam, Monica
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Sprache:eng
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Zusammenfassung:The safety of intensive blood pressure (BP) targets is controversial for persons with chronic kidney disease (CKD). We studied the effects of hypertension treatment on cerebral perfusion and structure in individuals with and without CKD. Neuroimaging substudy of a randomized trial. A subset of participants in the Systolic Blood Pressure Intervention Trial (SPRINT) who underwent brain magnetic resonance imaging studies. Presence of baseline CKD was assessed by estimated glomerular filtration rate (eGFR) and urinary albumin-creatinine ratio (UACR). Participants were randomly assigned to intensive (systolic BP 
ISSN:0272-6386
1523-6838
1523-6838
DOI:10.1053/j.ajkd.2021.07.024