In vitro activities of ketolides HRM 3647 and HRM 3004, levofloxacin, and other quinolones and macrolides against Neisseria spp. and Moraxella catarrhalis

In vitro activities of the ketolides HRM 3647 and HRM 3004 against pathogenic Neisseria gonorrhoeae and N. meningitidis , saprophytic Neisseria isolates, and Moraxella catarrhalis were determined. The comparison of ketolide activities with those of the other macrolides shows a much better activity in the majority of species, with macrolide MICs at which 90% of the isolates are inhibited between 8- and 10-fold higher.