Nobel somatosensations and pain

The Nobel prices 2021 for Physiology and Medicine have been awarded to David Julius and Ardem Patapoutian "for their discoveries of receptors for temperature and touch", TRPV1 and PIEZO1/2. The present review tells the past history of the capsaicin receptor, covers further selected TRP cha...

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Veröffentlicht in:	Pflügers Archiv 2022-04, Vol.474 (4), p.405-420
Hauptverfasser:	Reeh, Peter W., Fischer, Michael J. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidosis Binding sites Biomedical and Life Sciences Biomedicine Body temperature Capsaicin Capsaicin receptors Cell Biology Cloning Heat Human Physiology Humans Hyperalgesia Invited Review Ion Channels Kinases Microscopy Molecular Medicine Neurons Neurosciences Nobel Prize Pain Pain perception Physiology Receptors Skin Temperature TRPA1 Cation Channel TRPV Cation Channels
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Beschreibung
Zusammenfassung:	The Nobel prices 2021 for Physiology and Medicine have been awarded to David Julius and Ardem Patapoutian "for their discoveries of receptors for temperature and touch", TRPV1 and PIEZO1/2. The present review tells the past history of the capsaicin receptor, covers further selected TRP channels, TRPA1 in particular, and deals with mechanosensitivity in general and mechanical hyperalgesia in particular. Other achievements of the laureates and translational aspects of their work are shortly treated.
ISSN:	0031-6768 1432-2013
DOI:	10.1007/s00424-022-02667-x