Outcome after PSMA-PET/CT-based salvage radiotherapy for nodal recurrence after radical prostatectomy

Purpose Nodal recurrent prostate cancer (PCa) represents a common state of disease, amenable to local therapy. PSMA-PET/CT detects PCa recurrence at low PSA levels. The aim of this study was to evaluate the outcome of PSMA-PET/CT-based salvage radiotherapy (sRT) for lymph node (LN) recurrence. Metho...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of nuclear medicine and molecular imaging 2022-03, Vol.49 (4), p.1417-1428
Hauptverfasser:	Rogowski, Paul, Trapp, Christian, von Bestenbostel, Rieke, Eze, Chukwuka, Ganswindt, Ute, Li, Minglun, Unterrainer, Marcus, Zacherl, Mathias J., Ilhan, Harun, Beyer, Leonie, Kretschmer, Alexander, Bartenstein, Peter, Stief, Christian, Belka, Claus, Schmidt-Hegemann, Nina-Sophie
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen Antagonists Biochemistry Cancer surgery Cardiology Computed tomography Deprivation Gallium Radioisotopes Humans Imaging Localization Lymph nodes Lymphatic Metastasis Lymphatic system Male Medicine Medicine & Public Health Metastases Metastasis Multivariate analysis Neoplasm Recurrence, Local - diagnostic imaging Neoplasm Recurrence, Local - pathology Nuclear Medicine Oncology Oncology – Genitourinary Original Original Article Orthopedics Positron emission Positron Emission Tomography Computed Tomography Prostate cancer Prostate-Specific Antigen Prostatectomy Prostatic Neoplasms - diagnostic imaging Prostatic Neoplasms - radiotherapy Prostatic Neoplasms - surgery Radiation therapy Radiology Retrospective Studies Salvage Therapy Survival Tomography Urological surgery
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Purpose Nodal recurrent prostate cancer (PCa) represents a common state of disease, amenable to local therapy. PSMA-PET/CT detects PCa recurrence at low PSA levels. The aim of this study was to evaluate the outcome of PSMA-PET/CT-based salvage radiotherapy (sRT) for lymph node (LN) recurrence. Methods A total of 100 consecutive patients treated with PSMA-PET/CT-based salvage elective nodal radiotherapy (sENRT) for LN recurrence were retrospectively examined. Patients underwent PSMA-PET/CT scan due to biochemical persistence (bcP, 76%) or biochemical recurrence (bcR, 24%) after radical prostatectomy (RP). Biochemical recurrence-free survival (BRFS) defined as PSA
ISSN:	1619-7070 1619-7089
DOI:	10.1007/s00259-021-05557-z