Amphotericin B- and fluconazole-resistant Candida spp., Aspergillus fumigatus, and other newly emerging pathogenic fungi are susceptible to basic antifungal peptides

Amphotericin B- and fluconazole-resistant Candida spp., Aspergillus fumigatus, and other newly emerging pathogenic fungi are susceptible to basic antifungal peptides

The present study shows that a number of basic antifungal peptides, including human salivary histatin 5, a designed histatin analog designated dhvar4, and a peptide from frog skin, PGLa, are active against amphotericin B-resistant Candida albicans, Candida krusei, and Aspergillus fumigatus strains a...

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Veröffentlicht in:Antimicrobial agents and chemotherapy 1999-03, Vol.43 (3), p.702-704
Hauptverfasser: HELMERHORST, E. J, REIJNDERS, I. M, VAN'T HOF, W, SIMOONS-SMIT, I, VEERMAN, E. C. I, AMERONGEN, A. V. N
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Amphotericin B - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - pharmacology
Aspergillus fumigatus
Aspergillus fumigatus - drug effects
Aspergillus fumigatus - isolation & purification
Biological and medical sciences
Candida - drug effects
Candida - isolation & purification
Candida albicans
Candida glabrata
Candida krusei
Drug Resistance, Microbial
Drug Resistance, Multiple
Fluconazole - pharmacology
Fungi - drug effects
Fungi - isolation & purification
Histatins
Humans
Medical sciences
Microbial Sensitivity Tests
Molecular Sequence Data
Peptides - pharmacology
Pharmacology. Drug treatments
Salivary Proteins and Peptides - pharmacology
Susceptibility
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Zusammenfassung:The present study shows that a number of basic antifungal peptides, including human salivary histatin 5, a designed histatin analog designated dhvar4, and a peptide from frog skin, PGLa, are active against amphotericin B-resistant Candida albicans, Candida krusei, and Aspergillus fumigatus strains and against a fluconazole-resistant Candida glabrata isolate.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.43.3.702