AGE-DEPENDENT REDUCTION IN ASTHMATIC PATHOLOGY THROUGH REPROGAMMING OF POST-VIRAL INFLAMMATORY RESPONSES

Asthma is a chronic disease of childhood, but for unknown reasons disease activity sometimes subsides as children mature. Here, we present clinical and animal model evidence suggesting that the age-dependency of childhood asthma stems from an evolving host response to respiratory viral infection. Us...

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Veröffentlicht in:The Journal of immunology (1950) 2022-02, Vol.208 (6), p.1467-1482
Hauptverfasser: Hazan, Guy, Eubanks, Anna, Gierasch, Carrie, Atkinson, Jeffrey, Fox, Carolyn, Hernandez-Leyva, Ariel, Rosen, Anne L., Kau, Andrew L., Agapov, Eugene, Alexander-Brett, Jennifer, Steinberg, Deborah, Kelley, Diane, White, Michael, Byers, Derek, Wu, Kangyun, Keeler, Shamus P., Zhang, Yong, Koenitzer, Jeffrey R., Eiden, Elise, Anderson, Neil, Holtzman, Michael J., Haspel, Jeffrey
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Sprache:eng
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Zusammenfassung:Asthma is a chronic disease of childhood, but for unknown reasons disease activity sometimes subsides as children mature. Here, we present clinical and animal model evidence suggesting that the age-dependency of childhood asthma stems from an evolving host response to respiratory viral infection. Using clinical data, we show that societal suppression of respiratory virus transmission during COVID-19 lockdown disrupted the traditional age gradient in pediatric asthma exacerbations, connecting the phenomenon of asthma remission to virus exposure. In mice, we show that asthmatic lung pathology triggered by Sendai virus (SeV) or influenza A virus (IAV) is highly age-sensitive: robust in juvenile mice (4–6 weeks old) but attenuated in mature mice (>3 months old). Interestingly, allergen induction of the same asthmatic traits was less dependent on chronological age than viruses. Age-specific responses to SeV included a juvenile bias towards type-2 airway inflammation that emerged early in infection, while mature mice exhibited a more restricted bronchiolar distribution of infection that produced a distinct type-2 low inflammatory cytokine profile. In the basal state, aging produced changes to lung leukocyte burden, including the number and transcriptional landscape of alveolar macrophages (AMs). Importantly, depleting AMs in mature mice restored post-SeV pathology to juvenile levels. Thus, aging influences chronic outcomes of respiratory viral infection through regulation of the AM compartment and type-2 inflammatory responses to viruses. Our data provide insight into how asthma remission might develop in children.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.2101094