Nasopharyngeal Codetection of Haemophilus influenzae and Streptococcus pneumoniae Shapes Respiratory Syncytial Virus Disease Outcomes in Children

Abstract Background The role of nasopharyngeal bacteria in respiratory syncytial virus (RSV) disease has been underestimated. We measured the frequency and burden of respiratory bacteria in the upper respiratory tract of infants with RSV infection over 7 respiratory seasons, and their impact on clin...

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Veröffentlicht in:	The Journal of infectious diseases 2022-03, Vol.225 (5), p.912-923
Hauptverfasser:	Diaz-Diaz, Alejandro, Bunsow, Eleonora, Garcia-Maurino, Cristina, Moore-Clingenpeel, Melissa, Naples, Jeffrey, Juergensen, Alexis, Mertz, Sara, Wang, Huanyu, Leber, Amy L, Gern, James, Hall, Mark W, Cohen, Daniel M, Ramilo, Octavio, Mejias, Asuncion
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Bacteria Child Child, Preschool Children Communicable Diseases Fever Haemophilus influenzae Humans Infant Infants Leukocytes (neutrophilic) Major and Brief Reports Moraxella catarrhalis Nasopharynx - microbiology Penicillin Quantitation Respiratory syncytial virus Respiratory Syncytial Virus Infections - diagnosis Respiratory Syncytial Viruses Respiratory tract Staphylococcus aureus Streptococcus infections Streptococcus pneumoniae
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Zusammenfassung:	Abstract Background The role of nasopharyngeal bacteria in respiratory syncytial virus (RSV) disease has been underestimated. We measured the frequency and burden of respiratory bacteria in the upper respiratory tract of infants with RSV infection over 7 respiratory seasons, and their impact on clinical outcomes. Methods Children
ISSN:	0022-1899 1537-6613
DOI:	10.1093/infdis/jiab481