Fluidity is the way to life: lipid phase separation in bacterial membranes

A hallmark of biological membranes is the dynamic localization of lipids and proteins. Lipids respond to temperature reduction below a critical point with phase separation, and poikilothermic animals and also bacteria adapt their lipid content to prevent gel phase formation in membranes. In a new study, Gohrbandt et al (2022) show that reduced membrane fluidity in bacterial cells causes reversible phase separation without membrane rupture in vivo , highlighting the physical robustness of biological membranes. Graphical Abstract A new study provides a first example of a co‐existing gel/fluid phase separation in a bacterial cell.