SARS-CoV-2 vaccination washes away original antigenic sin

According to Röltgen and colleagues vaccination generates antibody breadth, whereas SARS-CoV-2 infection does not. Vaccination results in germinal center B cell responses and generates immunological breadth, with antibodies that bind viral variants. COVID-19 from SARS-CoV-2 infection does not induce...

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Veröffentlicht in:	Trends in immunology 2022-04, Vol.43 (4), p.271-273
1. Verfasser:	Pillai, Shiv
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antigens Coronaviruses COVID-19 COVID-19 - prevention & control COVID-19 Vaccines Germinal centers Humans Immune imprinting Immunology Infections Lymphatic system Pandemics Proteins SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Spotlight Vaccination
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Beschreibung
Zusammenfassung:	According to Röltgen and colleagues vaccination generates antibody breadth, whereas SARS-CoV-2 infection does not. Vaccination results in germinal center B cell responses and generates immunological breadth, with antibodies that bind viral variants. COVID-19 from SARS-CoV-2 infection does not induce germinal centers; it sustains immune imprinting, also known as ‘original antigenic sin’, and this results in limited immunological breadth.
ISSN:	1471-4906 1471-4981
DOI:	10.1016/j.it.2022.02.009