Prospective Study of Outcomes in Adults with Nonalcoholic Fatty Liver Disease
In a study involving patients with nonalcoholic fatty liver disease, all-cause mortality over a median of 4 years was higher among patients with advanced fibrosis at baseline than among those with lower fibrosis stages. Advanced fibrosis was related to an increased incidence of liver decompensation...
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| Veröffentlicht in: | The New England journal of medicine 2021-10, Vol.385 (17), p.1559-1569 |
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| container_title | The New England journal of medicine |
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| creator | Sanyal, Arun J Van Natta, Mark L Clark, Jeanne Neuschwander-Tetri, Brent A Diehl, AnnaMae Dasarathy, Srinivasan Loomba, Rohit Chalasani, Naga Kowdley, Kris Hameed, Bilal Wilson, Laura A Yates, Katherine P Belt, Patricia Lazo, Mariana Kleiner, David E Behling, Cynthia Tonascia, James |
| description | In a study involving patients with nonalcoholic fatty liver disease, all-cause mortality over a median of 4 years was higher among patients with advanced fibrosis at baseline than among those with lower fibrosis stages. Advanced fibrosis was related to an increased incidence of liver decompensation events. |
| doi_str_mv | 10.1056/NEJMoa2029349 |
| format | Article |
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All rights reserved.</rights><rights>Copyright © 2021 Massachusetts Medical Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-fc390620e2252013d69d16a1ccd75793796daad566adc3412e53bfe7682e3ee3</citedby><cites>FETCH-LOGICAL-c445t-fc390620e2252013d69d16a1ccd75793796daad566adc3412e53bfe7682e3ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa2029349$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2584000830?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,2759,2760,26103,27924,27925,52382,54064,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34670043$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sanyal, Arun J</creatorcontrib><creatorcontrib>Van Natta, Mark L</creatorcontrib><creatorcontrib>Clark, Jeanne</creatorcontrib><creatorcontrib>Neuschwander-Tetri, Brent A</creatorcontrib><creatorcontrib>Diehl, AnnaMae</creatorcontrib><creatorcontrib>Dasarathy, Srinivasan</creatorcontrib><creatorcontrib>Loomba, Rohit</creatorcontrib><creatorcontrib>Chalasani, Naga</creatorcontrib><creatorcontrib>Kowdley, Kris</creatorcontrib><creatorcontrib>Hameed, Bilal</creatorcontrib><creatorcontrib>Wilson, Laura A</creatorcontrib><creatorcontrib>Yates, Katherine P</creatorcontrib><creatorcontrib>Belt, Patricia</creatorcontrib><creatorcontrib>Lazo, Mariana</creatorcontrib><creatorcontrib>Kleiner, David E</creatorcontrib><creatorcontrib>Behling, Cynthia</creatorcontrib><creatorcontrib>Tonascia, James</creatorcontrib><creatorcontrib>NASH Clinical Research Network (CRN)</creatorcontrib><title>Prospective Study of Outcomes in Adults with Nonalcoholic Fatty Liver Disease</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>In a study involving patients with nonalcoholic fatty liver disease, all-cause mortality over a median of 4 years was higher among patients with advanced fibrosis at baseline than among those with lower fibrosis stages. Advanced fibrosis was related to an increased incidence of liver decompensation events.</description><subject>Adult</subject><subject>Adults</subject><subject>Ascites</subject><subject>Biopsy</subject><subject>Carcinoma, Hepatocellular - etiology</subject><subject>Cirrhosis</subject><subject>Clinical outcomes</subject><subject>Confidence intervals</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diet</subject><subject>Encephalopathy</subject><subject>Enrollments</subject><subject>Fatty liver</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Gastroenterology</subject><subject>Gastroenterology General</subject><subject>Gastrointestinal Hemorrhage - etiology</subject><subject>Glomerular filtration rate</subject><subject>Hemorrhage</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Incidence</subject><subject>Kidney diseases</subject><subject>Laboratories</subject><subject>Liver - pathology</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - complications</subject><subject>Liver Cirrhosis - mortality</subject><subject>Liver Disease</subject><subject>Liver diseases</subject><subject>Liver Neoplasms - etiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Non-alcoholic Fatty Liver Disease - complications</subject><subject>Non-alcoholic Fatty Liver Disease - mortality</subject><subject>Nutrition</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Severity of Illness Index</subject><subject>Software</subject><subject>Statistical analysis</subject><subject>Transplants & implants</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kc9LHDEcxYO06Gp77LUESsHLaH7P5CKI1dayaqHeQ0y-080yM9lOMpb9742uShX8XnL4fvLy8h5Cnyg5oESqw8vTnxfRMsI0F3oLzajkvBKCqHdoRghrKlFrvoN2U1qSMlTobbTDhaoJEXyGLn6NMa3A5XAL-Hee_BrHFl9N2cUeEg4DPvZTlxP-F_ICX8bBdi4uYhccPrM5r_G8XBzxt5DAJviA3re2S_Dx8dxD12en1yc_qvnV9_OT43nlhJC5ah3XRDECjElGKPdKe6osdc7XstittfLWeqmU9Y4LykDymxZq1TDgAHwPHW1kV9NND97BkEfbmdUYejuuTbTBvNwMYWH-xFvTNA3VjSwC-48CY_w7QcqmD8lB19kB4pQMk40sz0pNC_rlFbqM01hieKBEibThpFDVhnIlzjRC-2yGEnPfk3nRU-E___-DZ_qpmAJ83QB9n8wAy_4NoTt1r5l9</recordid><startdate>20211021</startdate><enddate>20211021</enddate><creator>Sanyal, Arun J</creator><creator>Van Natta, Mark L</creator><creator>Clark, Jeanne</creator><creator>Neuschwander-Tetri, Brent A</creator><creator>Diehl, AnnaMae</creator><creator>Dasarathy, Srinivasan</creator><creator>Loomba, Rohit</creator><creator>Chalasani, Naga</creator><creator>Kowdley, Kris</creator><creator>Hameed, Bilal</creator><creator>Wilson, Laura A</creator><creator>Yates, Katherine P</creator><creator>Belt, Patricia</creator><creator>Lazo, Mariana</creator><creator>Kleiner, David E</creator><creator>Behling, Cynthia</creator><creator>Tonascia, James</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20211021</creationdate><title>Prospective Study of Outcomes in Adults with Nonalcoholic Fatty Liver Disease</title><author>Sanyal, Arun J ; Van Natta, Mark L ; Clark, Jeanne ; Neuschwander-Tetri, Brent A ; Diehl, AnnaMae ; Dasarathy, Srinivasan ; Loomba, Rohit ; Chalasani, Naga ; Kowdley, Kris ; Hameed, Bilal ; Wilson, Laura A ; Yates, Katherine P ; Belt, Patricia ; Lazo, Mariana ; Kleiner, David E ; Behling, Cynthia ; Tonascia, James</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-fc390620e2252013d69d16a1ccd75793796daad566adc3412e53bfe7682e3ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Ascites</topic><topic>Biopsy</topic><topic>Carcinoma, Hepatocellular - 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| ispartof | The New England journal of medicine, 2021-10, Vol.385 (17), p.1559-1569 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Adult Adults Ascites Biopsy Carcinoma, Hepatocellular - etiology Cirrhosis Clinical outcomes Confidence intervals Diabetes Diabetes mellitus (non-insulin dependent) Diet Encephalopathy Enrollments Fatty liver Female Fibrosis Gastroenterology Gastroenterology General Gastrointestinal Hemorrhage - etiology Glomerular filtration rate Hemorrhage Humans Hypertension Incidence Kidney diseases Laboratories Liver - pathology Liver cancer Liver cirrhosis Liver Cirrhosis - complications Liver Cirrhosis - mortality Liver Disease Liver diseases Liver Neoplasms - etiology Male Middle Aged Mortality Non-alcoholic Fatty Liver Disease - complications Non-alcoholic Fatty Liver Disease - mortality Nutrition Prognosis Prospective Studies Severity of Illness Index Software Statistical analysis Transplants & implants |
| title | Prospective Study of Outcomes in Adults with Nonalcoholic Fatty Liver Disease |
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