Prospective Study of Outcomes in Adults with Nonalcoholic Fatty Liver Disease

In a study involving patients with nonalcoholic fatty liver disease, all-cause mortality over a median of 4 years was higher among patients with advanced fibrosis at baseline than among those with lower fibrosis stages. Advanced fibrosis was related to an increased incidence of liver decompensation...

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Veröffentlicht in:	The New England journal of medicine 2021-10, Vol.385 (17), p.1559-1569
Hauptverfasser:	Sanyal, Arun J, Van Natta, Mark L, Clark, Jeanne, Neuschwander-Tetri, Brent A, Diehl, AnnaMae, Dasarathy, Srinivasan, Loomba, Rohit, Chalasani, Naga, Kowdley, Kris, Hameed, Bilal, Wilson, Laura A, Yates, Katherine P, Belt, Patricia, Lazo, Mariana, Kleiner, David E, Behling, Cynthia, Tonascia, James
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adults Ascites Biopsy Carcinoma, Hepatocellular - etiology Cirrhosis Clinical outcomes Confidence intervals Diabetes Diabetes mellitus (non-insulin dependent) Diet Encephalopathy Enrollments Fatty liver Female Fibrosis Gastroenterology Gastroenterology General Gastrointestinal Hemorrhage - etiology Glomerular filtration rate Hemorrhage Humans Hypertension Incidence Kidney diseases Laboratories Liver - pathology Liver cancer Liver cirrhosis Liver Cirrhosis - complications Liver Cirrhosis - mortality Liver Disease Liver diseases Liver Neoplasms - etiology Male Middle Aged Mortality Non-alcoholic Fatty Liver Disease - complications Non-alcoholic Fatty Liver Disease - mortality Nutrition Prognosis Prospective Studies Severity of Illness Index Software Statistical analysis Transplants & implants
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Beschreibung
Zusammenfassung:	In a study involving patients with nonalcoholic fatty liver disease, all-cause mortality over a median of 4 years was higher among patients with advanced fibrosis at baseline than among those with lower fibrosis stages. Advanced fibrosis was related to an increased incidence of liver decompensation events.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2029349