Pilot Trial of Vitamin D3 and Calcifediol in Healthy Vitamin D Deficient Adults: Does It Change the Fecal Microbiome?

Experimental studies suggest that vitamin D receptor signaling may benefit the gut microbiome. In humans, whether vitamin D supplementation directly alters the gut microbiome is not well studied. To determine whether correcting vitamin D deficiency with cholecalciferol (vitamin D3, D3) or calcifedio...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2021-12, Vol.106 (12), p.3464-3476
Hauptverfasser:	Shieh, Albert, Lee, S Melanie, Lagishetty, Venu, Gottleib, Carter, Jacobs, Jonathan P, Adams, John S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Adults Alfacalcidol Analysis Biological diversity Biomarkers - blood Calcifediol Calcifediol - administration & dosage Cholecalciferol - administration & dosage Clinical Dietary Supplements Feces - microbiology Female Follow-Up Studies Gastrointestinal Microbiome Humans Male Microbiota (Symbiotic organisms) Phylogeny Pilot Projects Prognosis Vitamin D Vitamin D Deficiency - blood Vitamin D Deficiency - drug therapy Vitamin D Deficiency - microbiology Vitamin D Deficiency - pathology Vitamins - administration & dosage Young Adult
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Beschreibung
Zusammenfassung:	Experimental studies suggest that vitamin D receptor signaling may benefit the gut microbiome. In humans, whether vitamin D supplementation directly alters the gut microbiome is not well studied. To determine whether correcting vitamin D deficiency with cholecalciferol (vitamin D3, D3) or calcifediol (25-hydroxyvitamin D3, 25(OH)D3) changes gut microbiome composition. 18 adults with vitamin D deficiency (25-hydroxyvitamin D [25(OH)D]
ISSN:	0021-972X 1945-7197 1945-7197
DOI:	10.1210/clinem/dgab573