Staphylococcus aureus Efflux Pumps and Tolerance to Ciprofloxacin and Chlorhexidine following Induction by Mupirocin

Staphylococcus aureus Efflux Pumps and Tolerance to Ciprofloxacin and Chlorhexidine following Induction by Mupirocin

Mupirocin induced expression of genes encoding efflux pumps NorA and MepA as well as a yellow fluorescent protein (YFP) fluorescence reporter of NorA. Mupirocin exposure also produced reduced susceptibility to pump substrates ciprofloxacin and chlorhexidine, a change that was dependent on intact and...

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Veröffentlicht in:Antimicrobial agents and chemotherapy 2022-02, Vol.66 (2), p.e0184521-e0184521
Hauptverfasser: Truong-Bolduc, Q C, Wang, Y, Reedy, J L, Vyas, J M, Hooper, D C
Format: Artikel
Sprache:eng
Schlagworte:
Antimicrobial Chemotherapy
Mechanisms of Resistance
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Zusammenfassung:Mupirocin induced expression of genes encoding efflux pumps NorA and MepA as well as a yellow fluorescent protein (YFP) fluorescence reporter of NorA. Mupirocin exposure also produced reduced susceptibility to pump substrates ciprofloxacin and chlorhexidine, a change that was dependent on intact and , respectively.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.01845-21