Prefrontal and striatal dopamine D2/D3 receptors correlate with fMRI BOLD activation during stopping
D 2 -like dopamine receptors in animals and humans have been shown to be linked to impulsive behaviors that are highly relevant for several psychiatric disorders. Here, we investigate the relationship between the fronto-striatal D 2 /D 3 dopamine receptor availability and response inhibition in a se...
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Veröffentlicht in: | Brain imaging and behavior 2022-02, Vol.16 (1), p.186-198 |
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creator | Pfeifer, Philippe Sebastian, Alexandra Buchholz, Hans Georg Kaller, Christoph P. Gründer, Gerhard Fehr, Christoph Schreckenberger, Mathias Tüscher, Oliver |
description | D
2
-like dopamine receptors in animals and humans have been shown to be linked to impulsive behaviors that are highly relevant for several psychiatric disorders. Here, we investigate the relationship between the fronto-striatal D
2
/D
3
dopamine receptor availability and response inhibition in a selected population of healthy OPRM1 G-allele carriers. Twenty-two participants successively underwent blood-oxygen level dependent functional magnetic resonance imaging (fMRI) while performing a stop-signal task and a separate positron emission tomography (PET) scan. Striatal and extrastriatal D
2
/D
3
dopamine receptor availability was measured using the radiotracer [
18
F]fallypride. Caudate D
2
/D
3
dopamine receptor availability positively correlated with stopping-related fronto-striatal fMRI activation. In addition, right prefrontal D
2
/D
3
dopamine receptor availability correlated positively with stopping-related striatal fMRI BOLD signal. Our study partially replicates previous findings on correlations between striatal D
2
/D
3
dopamine receptor availability and response inhibition in a population selected for its genetic determination of dopamine response to alcohol and as a modulator of impulse control via the endogenous opioid system. We confirm the important role of D
2
/D
3
dopamine receptor availability in the fronto-striatal neural circuit for response inhibition. Moreover, we extend previous findings suggesting that dopamine receptor availability in the right inferior frontal cortex, a crucial region of the stopping network, is also strongly associated with stopping-related striatal fMRI activity in healthy OPRM1 G-allele carriers. |
doi_str_mv | 10.1007/s11682-021-00491-y |
format | Article |
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2
-like dopamine receptors in animals and humans have been shown to be linked to impulsive behaviors that are highly relevant for several psychiatric disorders. Here, we investigate the relationship between the fronto-striatal D
2
/D
3
dopamine receptor availability and response inhibition in a selected population of healthy OPRM1 G-allele carriers. Twenty-two participants successively underwent blood-oxygen level dependent functional magnetic resonance imaging (fMRI) while performing a stop-signal task and a separate positron emission tomography (PET) scan. Striatal and extrastriatal D
2
/D
3
dopamine receptor availability was measured using the radiotracer [
18
F]fallypride. Caudate D
2
/D
3
dopamine receptor availability positively correlated with stopping-related fronto-striatal fMRI activation. In addition, right prefrontal D
2
/D
3
dopamine receptor availability correlated positively with stopping-related striatal fMRI BOLD signal. Our study partially replicates previous findings on correlations between striatal D
2
/D
3
dopamine receptor availability and response inhibition in a population selected for its genetic determination of dopamine response to alcohol and as a modulator of impulse control via the endogenous opioid system. We confirm the important role of D
2
/D
3
dopamine receptor availability in the fronto-striatal neural circuit for response inhibition. Moreover, we extend previous findings suggesting that dopamine receptor availability in the right inferior frontal cortex, a crucial region of the stopping network, is also strongly associated with stopping-related striatal fMRI activity in healthy OPRM1 G-allele carriers.</description><identifier>ISSN: 1931-7557</identifier><identifier>ISSN: 1931-7565</identifier><identifier>EISSN: 1931-7565</identifier><identifier>DOI: 10.1007/s11682-021-00491-y</identifier><identifier>PMID: 34403039</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Alleles ; Availability ; Biomedical and Life Sciences ; Biomedicine ; Circuits ; Cortex (frontal) ; Dopamine ; Dopamine D2 receptors ; Dopamine D3 receptors ; Functional magnetic resonance imaging ; Impulsive behavior ; Magnetic resonance imaging ; Mental disorders ; Neostriatum ; Neuroimaging ; Neuropsychology ; Neuroradiology ; Neurosciences ; Opioid receptors ; Original Research ; Population genetics ; Positron emission ; Positron emission tomography ; Psychiatry ; Radioactive tracers ; Receptors ; Tomography</subject><ispartof>Brain imaging and behavior, 2022-02, Vol.16 (1), p.186-198</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021. The Author(s).</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420y-43b0a3d767da2ec6f6be5bd9feb30a782d58c7300ae6311fa250edc36ec82783</citedby><cites>FETCH-LOGICAL-c420y-43b0a3d767da2ec6f6be5bd9feb30a782d58c7300ae6311fa250edc36ec82783</cites><orcidid>0000-0001-8241-3682</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11682-021-00491-y$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11682-021-00491-y$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51298</link.rule.ids></links><search><creatorcontrib>Pfeifer, Philippe</creatorcontrib><creatorcontrib>Sebastian, Alexandra</creatorcontrib><creatorcontrib>Buchholz, Hans Georg</creatorcontrib><creatorcontrib>Kaller, Christoph P.</creatorcontrib><creatorcontrib>Gründer, Gerhard</creatorcontrib><creatorcontrib>Fehr, Christoph</creatorcontrib><creatorcontrib>Schreckenberger, Mathias</creatorcontrib><creatorcontrib>Tüscher, Oliver</creatorcontrib><title>Prefrontal and striatal dopamine D2/D3 receptors correlate with fMRI BOLD activation during stopping</title><title>Brain imaging and behavior</title><addtitle>Brain Imaging and Behavior</addtitle><description>D
2
-like dopamine receptors in animals and humans have been shown to be linked to impulsive behaviors that are highly relevant for several psychiatric disorders. Here, we investigate the relationship between the fronto-striatal D
2
/D
3
dopamine receptor availability and response inhibition in a selected population of healthy OPRM1 G-allele carriers. Twenty-two participants successively underwent blood-oxygen level dependent functional magnetic resonance imaging (fMRI) while performing a stop-signal task and a separate positron emission tomography (PET) scan. Striatal and extrastriatal D
2
/D
3
dopamine receptor availability was measured using the radiotracer [
18
F]fallypride. Caudate D
2
/D
3
dopamine receptor availability positively correlated with stopping-related fronto-striatal fMRI activation. In addition, right prefrontal D
2
/D
3
dopamine receptor availability correlated positively with stopping-related striatal fMRI BOLD signal. Our study partially replicates previous findings on correlations between striatal D
2
/D
3
dopamine receptor availability and response inhibition in a population selected for its genetic determination of dopamine response to alcohol and as a modulator of impulse control via the endogenous opioid system. We confirm the important role of D
2
/D
3
dopamine receptor availability in the fronto-striatal neural circuit for response inhibition. Moreover, we extend previous findings suggesting that dopamine receptor availability in the right inferior frontal cortex, a crucial region of the stopping network, is also strongly associated with stopping-related striatal fMRI activity in healthy OPRM1 G-allele carriers.</description><subject>Alleles</subject><subject>Availability</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Circuits</subject><subject>Cortex (frontal)</subject><subject>Dopamine</subject><subject>Dopamine D2 receptors</subject><subject>Dopamine D3 receptors</subject><subject>Functional magnetic resonance imaging</subject><subject>Impulsive behavior</subject><subject>Magnetic resonance imaging</subject><subject>Mental disorders</subject><subject>Neostriatum</subject><subject>Neuroimaging</subject><subject>Neuropsychology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Opioid receptors</subject><subject>Original 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Philippe</creator><creator>Sebastian, Alexandra</creator><creator>Buchholz, Hans Georg</creator><creator>Kaller, Christoph P.</creator><creator>Gründer, Gerhard</creator><creator>Fehr, Christoph</creator><creator>Schreckenberger, Mathias</creator><creator>Tüscher, Oliver</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8241-3682</orcidid></search><sort><creationdate>20220201</creationdate><title>Prefrontal and striatal dopamine D2/D3 receptors correlate with fMRI BOLD activation during stopping</title><author>Pfeifer, Philippe ; Sebastian, Alexandra ; Buchholz, Hans Georg ; Kaller, Christoph P. ; Gründer, Gerhard ; Fehr, Christoph ; Schreckenberger, Mathias ; Tüscher, Oliver</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420y-43b0a3d767da2ec6f6be5bd9feb30a782d58c7300ae6311fa250edc36ec82783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alleles</topic><topic>Availability</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Circuits</topic><topic>Cortex (frontal)</topic><topic>Dopamine</topic><topic>Dopamine D2 receptors</topic><topic>Dopamine D3 receptors</topic><topic>Functional magnetic resonance imaging</topic><topic>Impulsive behavior</topic><topic>Magnetic resonance imaging</topic><topic>Mental disorders</topic><topic>Neostriatum</topic><topic>Neuroimaging</topic><topic>Neuropsychology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Opioid receptors</topic><topic>Original Research</topic><topic>Population genetics</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Psychiatry</topic><topic>Radioactive tracers</topic><topic>Receptors</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pfeifer, Philippe</creatorcontrib><creatorcontrib>Sebastian, Alexandra</creatorcontrib><creatorcontrib>Buchholz, Hans Georg</creatorcontrib><creatorcontrib>Kaller, Christoph P.</creatorcontrib><creatorcontrib>Gründer, Gerhard</creatorcontrib><creatorcontrib>Fehr, Christoph</creatorcontrib><creatorcontrib>Schreckenberger, Mathias</creatorcontrib><creatorcontrib>Tüscher, Oliver</creatorcontrib><collection>Springer Nature OA Free 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Mathias</au><au>Tüscher, Oliver</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prefrontal and striatal dopamine D2/D3 receptors correlate with fMRI BOLD activation during stopping</atitle><jtitle>Brain imaging and behavior</jtitle><stitle>Brain Imaging and Behavior</stitle><date>2022-02-01</date><risdate>2022</risdate><volume>16</volume><issue>1</issue><spage>186</spage><epage>198</epage><pages>186-198</pages><issn>1931-7557</issn><issn>1931-7565</issn><eissn>1931-7565</eissn><abstract>D
2
-like dopamine receptors in animals and humans have been shown to be linked to impulsive behaviors that are highly relevant for several psychiatric disorders. Here, we investigate the relationship between the fronto-striatal D
2
/D
3
dopamine receptor availability and response inhibition in a selected population of healthy OPRM1 G-allele carriers. Twenty-two participants successively underwent blood-oxygen level dependent functional magnetic resonance imaging (fMRI) while performing a stop-signal task and a separate positron emission tomography (PET) scan. Striatal and extrastriatal D
2
/D
3
dopamine receptor availability was measured using the radiotracer [
18
F]fallypride. Caudate D
2
/D
3
dopamine receptor availability positively correlated with stopping-related fronto-striatal fMRI activation. In addition, right prefrontal D
2
/D
3
dopamine receptor availability correlated positively with stopping-related striatal fMRI BOLD signal. Our study partially replicates previous findings on correlations between striatal D
2
/D
3
dopamine receptor availability and response inhibition in a population selected for its genetic determination of dopamine response to alcohol and as a modulator of impulse control via the endogenous opioid system. We confirm the important role of D
2
/D
3
dopamine receptor availability in the fronto-striatal neural circuit for response inhibition. Moreover, we extend previous findings suggesting that dopamine receptor availability in the right inferior frontal cortex, a crucial region of the stopping network, is also strongly associated with stopping-related striatal fMRI activity in healthy OPRM1 G-allele carriers.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>34403039</pmid><doi>10.1007/s11682-021-00491-y</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-8241-3682</orcidid><oa>free_for_read</oa></addata></record> |
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source | Springer Nature - Complete Springer Journals |
subjects | Alleles Availability Biomedical and Life Sciences Biomedicine Circuits Cortex (frontal) Dopamine Dopamine D2 receptors Dopamine D3 receptors Functional magnetic resonance imaging Impulsive behavior Magnetic resonance imaging Mental disorders Neostriatum Neuroimaging Neuropsychology Neuroradiology Neurosciences Opioid receptors Original Research Population genetics Positron emission Positron emission tomography Psychiatry Radioactive tracers Receptors Tomography |
title | Prefrontal and striatal dopamine D2/D3 receptors correlate with fMRI BOLD activation during stopping |
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