Prefrontal and striatal dopamine D2/D3 receptors correlate with fMRI BOLD activation during stopping

D 2 -like dopamine receptors in animals and humans have been shown to be linked to impulsive behaviors that are highly relevant for several psychiatric disorders. Here, we investigate the relationship between the fronto-striatal D 2 /D 3 dopamine receptor availability and response inhibition in a se...

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Veröffentlicht in:Brain imaging and behavior 2022-02, Vol.16 (1), p.186-198
Hauptverfasser: Pfeifer, Philippe, Sebastian, Alexandra, Buchholz, Hans Georg, Kaller, Christoph P., Gründer, Gerhard, Fehr, Christoph, Schreckenberger, Mathias, Tüscher, Oliver
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container_title Brain imaging and behavior
container_volume 16
creator Pfeifer, Philippe
Sebastian, Alexandra
Buchholz, Hans Georg
Kaller, Christoph P.
Gründer, Gerhard
Fehr, Christoph
Schreckenberger, Mathias
Tüscher, Oliver
description D 2 -like dopamine receptors in animals and humans have been shown to be linked to impulsive behaviors that are highly relevant for several psychiatric disorders. Here, we investigate the relationship between the fronto-striatal D 2 /D 3 dopamine receptor availability and response inhibition in a selected population of healthy OPRM1 G-allele carriers. Twenty-two participants successively underwent blood-oxygen level dependent functional magnetic resonance imaging (fMRI) while performing a stop-signal task and a separate positron emission tomography (PET) scan. Striatal and extrastriatal D 2 /D 3 dopamine receptor availability was measured using the radiotracer [ 18 F]fallypride. Caudate D 2 /D 3 dopamine receptor availability positively correlated with stopping-related fronto-striatal fMRI activation. In addition, right prefrontal D 2 /D 3 dopamine receptor availability correlated positively with stopping-related striatal fMRI BOLD signal. Our study partially replicates previous findings on correlations between striatal D 2 /D 3 dopamine receptor availability and response inhibition in a population selected for its genetic determination of dopamine response to alcohol and as a modulator of impulse control via the endogenous opioid system. We confirm the important role of D 2 /D 3 dopamine receptor availability in the fronto-striatal neural circuit for response inhibition. Moreover, we extend previous findings suggesting that dopamine receptor availability in the right inferior frontal cortex, a crucial region of the stopping network, is also strongly associated with stopping-related striatal fMRI activity in healthy OPRM1 G-allele carriers.
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source Springer Nature - Complete Springer Journals
subjects Alleles
Availability
Biomedical and Life Sciences
Biomedicine
Circuits
Cortex (frontal)
Dopamine
Dopamine D2 receptors
Dopamine D3 receptors
Functional magnetic resonance imaging
Impulsive behavior
Magnetic resonance imaging
Mental disorders
Neostriatum
Neuroimaging
Neuropsychology
Neuroradiology
Neurosciences
Opioid receptors
Original Research
Population genetics
Positron emission
Positron emission tomography
Psychiatry
Radioactive tracers
Receptors
Tomography
title Prefrontal and striatal dopamine D2/D3 receptors correlate with fMRI BOLD activation during stopping
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