SARS-CoV-2 Omicron Variant Neutralization after mRNA-1273 Booster Vaccination

Neutralization of the omicron variant was assessed in serum samples obtained from persons who had received an mRNA-1273 booster. After the standard two-dose vaccine regimen, these titers were approximately 35 times lower than those against the D614G variant. However, boosters increased omicron neutr...

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Veröffentlicht in:	The New England journal of medicine 2022-03, Vol.386 (11), p.1088-1091
Hauptverfasser:	Pajon, Rolando, Doria-Rose, Nicole A, Shen, Xiaoying, Schmidt, Stephen D, O’Dell, Sijy, McDanal, Charlene, Feng, Wenhong, Tong, Jin, Eaton, Amanda, Maglinao, Maha, Tang, Haili, Manning, Kelly E, Edara, Venkata-Viswanadh, Lai, Lilin, Ellis, Madison, Moore, Kathryn M, Floyd, Katharine, Foster, Stephanie L, Posavad, Christine M, Atmar, Robert L, Lyke, Kirsten E, Zhou, Tongqing, Wang, Lingshu, Zhang, Yi, Gaudinski, Martin R, Black, Walker P, Gordon, Ingelise, Guech, Mercy, Ledgerwood, Julie E, Misasi, John N, Widge, Alicia, Sullivan, Nancy J, Roberts, Paul C, Beigel, John H, Korber, Bette, Baden, Lindsey R, El Sahly, Hana, Chalkias, Spyros, Zhou, Honghong, Feng, Jing, Girard, Bethany, Das, Rituparna, Aunins, Anne, Edwards, Darin K, Suthar, Mehul S, Mascola, John R, Montefiori, David C
Format:	Artikel
Sprache:	eng
Schlagworte:	Coronavirus Coronaviruses Correspondence COVID-19 vaccines HIV Human immunodeficiency virus Immunization Infectious Disease Infectious diseases Laboratories Medical research mRNA Mutation R&D Research & development Severe acute respiratory syndrome coronavirus 2 Vaccination Vaccines Viral Infections
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Beschreibung
Zusammenfassung:	Neutralization of the omicron variant was assessed in serum samples obtained from persons who had received an mRNA-1273 booster. After the standard two-dose vaccine regimen, these titers were approximately 35 times lower than those against the D614G variant. However, boosters increased omicron neutralization by a factor of 20 — to levels that correlate with clinical resistance to infection.
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMc2119912