Controls and Result Interpretations in Studies of Urine Gluten Peptide Determinations

(1), in which the authors assess the diagnostic performance of urinary gluten immunogenic peptides (GIP) determination to detect gluten contamination of the gluten-free diet (GFD) in a group of healthy and qualified Italian volunteers adhering to GFD and undergoing repeated dietary challenges with increasing amounts of gluten. [...]to over a dozen studies from multiple groups reporting the validity, utility, and reliability of the GIP tests in the monitoring of the GFD (2), this is the first study to date suggesting that the urine GIP test was not reliable because of a high frequency of reported false positive and negative determinations. [...]the suggestions of Monachesi et al.