Beclin-1 expression serves as an important biomarker for carcinogenesis and evolution in lung adenocarcinoma presenting as ground glass opacity
The prognostic impact of and relationship between expression and carcinogenesis of lung adenocarcinoma has not been clarified. The data of 10 patients with atypical adenomatoid hyperplasia (AAH), 20 patients with adenocarcinoma in situ (AIS), 28 patients with minimally invasive adenocarcinoma (MIA),...
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| Veröffentlicht in: | Translational cancer research 2020-07, Vol.9 (7), p.4204-4211 |
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| container_title | Translational cancer research |
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| creator | Chen, Ling Du, Hailei Luo, Fangxiu Chen, Xueyu Li, Yong Cheng, Qijian |
| description | The prognostic impact of
and relationship between
expression and carcinogenesis of lung adenocarcinoma has not been clarified.
The data of 10 patients with atypical adenomatoid hyperplasia (AAH), 20 patients with adenocarcinoma in situ (AIS), 28 patients with minimally invasive adenocarcinoma (MIA), and 50 patients with invasive adenocarcinoma (IA) who underwent surgical resection, were retrospectively reviewed. Normal lung tissues (NTs) were also collected for comparison. The expression levels of
mRNA and protein were detected by RT-PCR and western blotting, respectively. Immunohistochemistry was also performed.
The transcriptional expression of
in lung adenocarcinoma presenting as GGO was significantly lower than that in NTs (P |
| doi_str_mv | 10.21037/tcr-20-1001 |
| format | Article |
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and relationship between
expression and carcinogenesis of lung adenocarcinoma has not been clarified.
The data of 10 patients with atypical adenomatoid hyperplasia (AAH), 20 patients with adenocarcinoma in situ (AIS), 28 patients with minimally invasive adenocarcinoma (MIA), and 50 patients with invasive adenocarcinoma (IA) who underwent surgical resection, were retrospectively reviewed. Normal lung tissues (NTs) were also collected for comparison. The expression levels of
mRNA and protein were detected by RT-PCR and western blotting, respectively. Immunohistochemistry was also performed.
The transcriptional expression of
in lung adenocarcinoma presenting as GGO was significantly lower than that in NTs (P<0.05), and patients with MIA and IA showed a lower expression of
than that in patients with AAH and AIS (P<0.01). Lung adenocarcinomas with low expression of
were in more advanced stage (stage 0-I
stageII_III: 0.24±0.11
0.17±0.03, P<0.01), had more lymph node metastasis (P<0.01), and were of more invasive pathological subtype (P<0.01) than lung adenocarcinomas with high expression of
. Low expression of
predicted worse survival in patients with IA (P<0.05).
expression was related with the evolution of lung adenocarcinoma.
may be an important marker for predicting the prognosis of patients with lung adenocarcinoma manifested as GGO.]]></description><identifier>ISSN: 2218-676X</identifier><identifier>EISSN: 2219-6803</identifier><identifier>DOI: 10.21037/tcr-20-1001</identifier><identifier>PMID: 35117788</identifier><language>eng</language><publisher>China: AME Publishing Company</publisher><subject>Original</subject><ispartof>Translational cancer research, 2020-07, Vol.9 (7), p.4204-4211</ispartof><rights>2020 Translational Cancer Research. All rights reserved.</rights><rights>2020 Translational Cancer Research. All rights reserved. 2020 Translational Cancer Research.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799113/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799113/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35117788$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Ling</creatorcontrib><creatorcontrib>Du, Hailei</creatorcontrib><creatorcontrib>Luo, Fangxiu</creatorcontrib><creatorcontrib>Chen, Xueyu</creatorcontrib><creatorcontrib>Li, Yong</creatorcontrib><creatorcontrib>Cheng, Qijian</creatorcontrib><title>Beclin-1 expression serves as an important biomarker for carcinogenesis and evolution in lung adenocarcinoma presenting as ground glass opacity</title><title>Translational cancer research</title><addtitle>Transl Cancer Res</addtitle><description><![CDATA[The prognostic impact of
and relationship between
expression and carcinogenesis of lung adenocarcinoma has not been clarified.
The data of 10 patients with atypical adenomatoid hyperplasia (AAH), 20 patients with adenocarcinoma in situ (AIS), 28 patients with minimally invasive adenocarcinoma (MIA), and 50 patients with invasive adenocarcinoma (IA) who underwent surgical resection, were retrospectively reviewed. Normal lung tissues (NTs) were also collected for comparison. The expression levels of
mRNA and protein were detected by RT-PCR and western blotting, respectively. Immunohistochemistry was also performed.
The transcriptional expression of
in lung adenocarcinoma presenting as GGO was significantly lower than that in NTs (P<0.05), and patients with MIA and IA showed a lower expression of
than that in patients with AAH and AIS (P<0.01). Lung adenocarcinomas with low expression of
were in more advanced stage (stage 0-I
stageII_III: 0.24±0.11
0.17±0.03, P<0.01), had more lymph node metastasis (P<0.01), and were of more invasive pathological subtype (P<0.01) than lung adenocarcinomas with high expression of
. Low expression of
predicted worse survival in patients with IA (P<0.05).
expression was related with the evolution of lung adenocarcinoma.
may be an important marker for predicting the prognosis of patients with lung adenocarcinoma manifested as GGO.]]></description><subject>Original</subject><issn>2218-676X</issn><issn>2219-6803</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpVkUFv1jAMhisEYtO2G2eUIwcKcdIm6QUJJmCTJu0CErfIX-qWQJuUpP20_Yr9ZdrtY2KSJVvy49e23qJ4BfydAC71-9mlUvASOIdnxbEQ0JTKcPn8vjal0urHUXGW8y_OuQAwFVcviyNZA2htzHFx94nc4EMJjG6mRDn7GFimtKfMcI3A_DjFNGOY2c7HEdNvSqyLiTlMzofYU6DsN7JltI_DMm8KPrBhCT3DlkI8kCOybQOF2W-dzPoUl3WqHzBnFid0fr49LV50OGQ6O-ST4vuXz9_OL8qr66-X5x-vSicrmEtsXFVD1RnQQEqKjhtCbFUrd67TBo2p3K5uAHXbcW2EBN4iVbVreQdN1ciT4sOD7rTsRmrdelXCwU7Jry_e2ojePu0E_9P2cW-NbhoAuQq8OQik-GehPNvRZ0fDgIHikq1QQnGuamNW9O0D6lLMOVH3uAa4vbfRrjZawe1m44q__v-0R_ifafIvrOqdiw</recordid><startdate>202007</startdate><enddate>202007</enddate><creator>Chen, Ling</creator><creator>Du, Hailei</creator><creator>Luo, Fangxiu</creator><creator>Chen, Xueyu</creator><creator>Li, Yong</creator><creator>Cheng, Qijian</creator><general>AME Publishing Company</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202007</creationdate><title>Beclin-1 expression serves as an important biomarker for carcinogenesis and evolution in lung adenocarcinoma presenting as ground glass opacity</title><author>Chen, Ling ; Du, Hailei ; Luo, Fangxiu ; Chen, Xueyu ; Li, Yong ; Cheng, Qijian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c341t-a9c4514f8171e632f08eaad6d3bcf78a884cb591a7df0782310dae45cd0f19493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Original</topic><toplevel>online_resources</toplevel><creatorcontrib>Chen, Ling</creatorcontrib><creatorcontrib>Du, Hailei</creatorcontrib><creatorcontrib>Luo, Fangxiu</creatorcontrib><creatorcontrib>Chen, Xueyu</creatorcontrib><creatorcontrib>Li, Yong</creatorcontrib><creatorcontrib>Cheng, Qijian</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Translational cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Ling</au><au>Du, Hailei</au><au>Luo, Fangxiu</au><au>Chen, Xueyu</au><au>Li, Yong</au><au>Cheng, Qijian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beclin-1 expression serves as an important biomarker for carcinogenesis and evolution in lung adenocarcinoma presenting as ground glass opacity</atitle><jtitle>Translational cancer research</jtitle><addtitle>Transl Cancer Res</addtitle><date>2020-07</date><risdate>2020</risdate><volume>9</volume><issue>7</issue><spage>4204</spage><epage>4211</epage><pages>4204-4211</pages><issn>2218-676X</issn><eissn>2219-6803</eissn><abstract><![CDATA[The prognostic impact of
and relationship between
expression and carcinogenesis of lung adenocarcinoma has not been clarified.
The data of 10 patients with atypical adenomatoid hyperplasia (AAH), 20 patients with adenocarcinoma in situ (AIS), 28 patients with minimally invasive adenocarcinoma (MIA), and 50 patients with invasive adenocarcinoma (IA) who underwent surgical resection, were retrospectively reviewed. Normal lung tissues (NTs) were also collected for comparison. The expression levels of
mRNA and protein were detected by RT-PCR and western blotting, respectively. Immunohistochemistry was also performed.
The transcriptional expression of
in lung adenocarcinoma presenting as GGO was significantly lower than that in NTs (P<0.05), and patients with MIA and IA showed a lower expression of
than that in patients with AAH and AIS (P<0.01). Lung adenocarcinomas with low expression of
were in more advanced stage (stage 0-I
stageII_III: 0.24±0.11
0.17±0.03, P<0.01), had more lymph node metastasis (P<0.01), and were of more invasive pathological subtype (P<0.01) than lung adenocarcinomas with high expression of
. Low expression of
predicted worse survival in patients with IA (P<0.05).
expression was related with the evolution of lung adenocarcinoma.
may be an important marker for predicting the prognosis of patients with lung adenocarcinoma manifested as GGO.]]></abstract><cop>China</cop><pub>AME Publishing Company</pub><pmid>35117788</pmid><doi>10.21037/tcr-20-1001</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Original |
| title | Beclin-1 expression serves as an important biomarker for carcinogenesis and evolution in lung adenocarcinoma presenting as ground glass opacity |
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