Increased risk of infection with SARS-CoV-2 Omicron BA.1 compared with Delta in vaccinated and previously infected individuals, the Netherlands, 22 November 2021 to 19 January 2022

Infections with the Omicron SARS-CoV-2 variant are rapidly increasing worldwide. Among 174,349 SARS-CoV-2-infected individuals (≥ 12 years), we observed an increased risk of S gene target failure, predictive of the Omicron variant, in vaccinated (odds ratio (OR): 3.6; 95% confidence interval (CI): 3...

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Veröffentlicht in:	Euro surveillance : bulletin européen sur les maladies transmissibles 2022-01, Vol.27 (4)
Hauptverfasser:	Eggink, Dirk, Andeweg, Stijn P, Vennema, Harry, van Maarseveen, Noortje, Vermaas, Klaas, Vlaemynck, Boris, Schepers, Raf, van Gageldonk-Lafeber, Arianne B, van den Hof, Susan, Reusken, Chantal Bem, Knol, Mirjam J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies COVID-19 COVID-19 Vaccines Glycoproteins Health risk assessment Humans Netherlands Rapid Communication Risk factors SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2
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Zusammenfassung:	Infections with the Omicron SARS-CoV-2 variant are rapidly increasing worldwide. Among 174,349 SARS-CoV-2-infected individuals (≥ 12 years), we observed an increased risk of S gene target failure, predictive of the Omicron variant, in vaccinated (odds ratio (OR): 3.6; 95% confidence interval (CI): 3.4-3.7) and previously infected individuals (OR: 4.2; 95% CI: 3.8-4.7) compared with infected naïve individuals. This suggests vaccine- or infection-induced immunity against SARS-CoV-2 infections is less effective against the Omicron than the Delta variant.
ISSN:	1560-7917 1025-496X 1560-7917
DOI:	10.2807/1560-7917.ES.2022.27.4.2101196