Recombinant human interferon-α1b inhibits SARS-CoV-2 better than interferon-α2b in vitro

•A comprehensive evaluation method for anti-SARS-CoV-2 drugs was established based on qPCR, TCID50, and immunofluorescence.•A significant antiviral effect of rHuIFN-α1b was shown in Vero and Calu-3 cells.•rHuIFN-α1b has a good potential in the application of anti-COVID-19 therapy.

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Bibliographische Detailangaben
Veröffentlicht in:	Virologica Sinica 2022-04, Vol.37 (2), p.295-298
Hauptverfasser:	Shi, Danrong, Chen, Keda, Lu, Xiangyun, Cheng, Linfang, Weng, Tianhao, Liu, Fumin, Wu, Nanping, Li, Lanjuan, Yao, Hangping
Format:	Artikel
Sprache:	eng
Schlagworte:	Letter
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	•A comprehensive evaluation method for anti-SARS-CoV-2 drugs was established based on qPCR, TCID50, and immunofluorescence.•A significant antiviral effect of rHuIFN-α1b was shown in Vero and Calu-3 cells.•rHuIFN-α1b has a good potential in the application of anti-COVID-19 therapy.
ISSN:	1995-820X 1674-0769 1995-820X
DOI:	10.1016/j.virs.2022.01.031