COVID-19 reinfection after pregnancy

•Report of a case of COVID-19 reinfection with a first mild infection during late pregnancy and a more aggressive second infection 5 months later.•Reinfection due to a variant viral strain could be a possibility as numerous new and more aggressive variants are described.•Apparent paradox between declining antibody levels and low incidence of reinfection, implying other immune mechanisms at work, including T lymphocytes.•The role of HLA-G immuno-inhibitor may be questioned and may be a possible treatment. There have been reports of COVID-19 reinfections, but the immunological characterization of these cases is partial. We report a case of reinfection with SARS-CoV-2, where the first infection occurred in the course of late pregnancy. On May 27, 2020, a 37-year-old woman gave birth at full term, 3 hours after full dilatation. She developed fever (38.3°C) after delivery. Mild biological anomalies compatible with COVID-19 were observed: lymphopenia, thrombocytopenia, elevated D-Dimers, CRP, and LDH. At 6-month follow-up, she reported having contracted COVID-19 with high fever, rhinorrhea, hand frostbites, cough, headache, dysgeusia and anosmia. We report a case of COVID-19 reinfection with a first mild infection during late pregnancy and a more aggressive second infection 5 months later.