The antibody response to SARS-CoV-2 infection persists over at least 8 months in symptomatic patients

Background Persistence of antibodies to SARS-CoV-2 viral infection may depend on several factors and may be related to the severity of disease or to the different symptoms. Methods We evaluated the antibody response to SARS-CoV-2 in personnel from 9 healthcare facilities and an international medical school and its association with individuals’ characteristics and COVID-19 symptoms in an observational cohort study. We enrolled 4735 subjects (corresponding to 80% of all personnel) for three time points over a period of 8–10 months. For each participant, we determined the rate of antibody increase or decrease over time in relation to 93 features analyzed in univariate and multivariate analyses through a machine learning approach. Results Here we show in individuals positive for IgG (≥12 AU/mL) at the beginning of the study an increase [ p = 0 . 0002 ] in antibody response in paucisymptomatic or symptomatic subjects, particularly with loss of taste or smell (anosmia/dysgeusia: OR 2.75, 95% CI 1.753 – 4.301), in a multivariate logistic regression analysis in the first three months. The antibody response persists for at least 8–10 months. Conclusions SARS-CoV-2 infection induces a long lasting antibody response that increases in the first months, particularly in individuals with anosmia/dysgeusia. This may be linked to the lingering of SARS-CoV-2 in the olfactory bulb. Levi and Ubaldi et al. evaluate SARS-CoV-2 seroprevalence in a cohort of 4735 healthcare workers in northern Italy. In seropositive individuals, they show that antibodies are maintained over a period of 8 to 10 months and associate changes in antibody levels over this period with symptoms and specific subgroups of participants. Plain language summary SARS-CoV-2 infection activates the body’s immune system to fight off infection. This immune response results in the production of proteins in the blood that target the virus called antibodies. The extent and duration of this antibody response may be associated with the type of symptoms the infected person is experiencing. Here, we analyzed SARS-CoV-2 antibody levels in individuals with asymptomatic, mild symptomatic (paucisymptomatic) and symptomatic disease in relation to the type of symptoms. We find that the antibody response is higher in people with symptoms and increases in the first three months, particularly in individuals with loss of smell or taste. In all people with SARS-CoV-2 antibodies at the start of the study, levels in the blood la