Beta-Blocker Use in Hypertension and Heart Failure (A Secondary Analysis of the Systolic Blood Pressure Intervention Trial)

Given the concern that beta-blocker use may be associated with an increased risk for heart failure (HF) in populations with normal left ventricular systolic function, we evaluated the association between beta-blocker use and incident HF events, as well as loop diuretic initiation in the Systolic Blo...

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Veröffentlicht in:	The American journal of cardiology 2022-02, Vol.165, p.58-64
Hauptverfasser:	Silverman, Daniel N., de Lavallaz, Jeanne du Fay, Plante, Timothy B., Infeld, Margaret M., Goyal, Parag, Juraschek, Stephen P., Dougherty, Geoff B., Callas, Peter W., Meyer, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute coronary syndromes Adrenergic beta-Antagonists - therapeutic use Aged Antihypertensive Agents - therapeutic use Antihypertensives Aortic aneurysms Atrial Fibrillation - epidemiology Beta blockers Blood Pressure Cardiovascular disease Cardiovascular diseases Confidence intervals Congestive heart failure Coronary artery Coronary artery disease Coronary Artery Disease - epidemiology Coronary vessels Diuretics Electrocardiography Enrollments Female Fibrillation Health hazards Health risks Heart failure Heart Failure - epidemiology Heart rate Humans Hypertension Hypertension - drug therapy Hypertension - epidemiology Incidence Male Middle Aged Morbidity Patient Care Planning Patients Propensity Score Proportional Hazards Models Risk analysis Risk Factors Secondary analysis Sensitivity analysis Sodium Potassium Chloride Symporter Inhibitors - therapeutic use Stroke Survival analysis Vein & artery diseases Ventricle Vital signs
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Zusammenfassung:	Given the concern that beta-blocker use may be associated with an increased risk for heart failure (HF) in populations with normal left ventricular systolic function, we evaluated the association between beta-blocker use and incident HF events, as well as loop diuretic initiation in the Systolic Blood Pressure Intervention Trial (SPRINT). SPRINT demonstrated that a blood pressure target of
ISSN:	0002-9149 1879-1913
DOI:	10.1016/j.amjcard.2021.10.049