cADPR induced calcium influx mediates axonal degeneration caused by paclitaxel

cADPR induced calcium influx mediates axonal degeneration caused by paclitaxel

Activation of the NAD hydrolase domain of Sarm1 mediates axonal degeneration caused by chemotherapy drugs, but the downstream events are unknown. In this issue, Li and colleagues (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202106080) demonstrate that cADPR, a breakdown product of NAD, mediates p...

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Veröffentlicht in:The Journal of cell biology 2022-02, Vol.221 (2), p.1
1. Verfasser: Höke, Ahmet
Format: Artikel
Sprache:eng
Schlagworte:
Armadillo Domain Proteins
Axons
Calcium
Calcium influx
Chemotherapy
Cyclic ADP-Ribose
Cytoskeletal Proteins
Degeneration
Hydrolase
NAD
Neurodegeneration
Paclitaxel
Paclitaxel - adverse effects
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Zusammenfassung:Activation of the NAD hydrolase domain of Sarm1 mediates axonal degeneration caused by chemotherapy drugs, but the downstream events are unknown. In this issue, Li and colleagues (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202106080) demonstrate that cADPR, a breakdown product of NAD, mediates paclitaxel-induced axonal degeneration by promoting influx of calcium into the axons.
ISSN:0021-9525
1540-8140
1540-8140
DOI:10.1083/jcb.202112021