A Comparative Photophysical Study of Structural Modifications of Thioflavin T‑Inspired Fluorophores

The benzothiazolium salt, Thioflavin T (ThT), has been widely adopted as the “gold-standard” fluorescent reporter of amyloid in vitro. Its properties as a molecular rotor result in a large-scale (∼1000-fold) fluorescence turn-on upon binding to β-sheets in amyloidogenic proteins. However, the comple...

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Veröffentlicht in:	The journal of physical chemistry letters 2020-10, Vol.11 (19), p.8406-8416
Hauptverfasser:	Needham, Lisa-Maria, Weber, Judith, Pearson, Colin M, Do, Dung T, Gorka, Felix, Lyu, Guanpeng, Bohndiek, Sarah E, Snaddon, Thomas N, Lee, Steven F
Format:	Artikel
Sprache:	eng
Schlagworte:	Physical Insights into Light Interacting with Matter
Online-Zugang:	Volltext
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