Circulating Free Fatty Acid and Phospholipid Signature Predicts Early Rapid Kidney Function Decline in Patients With Type 1 Diabetes

Circulating Free Fatty Acid and Phospholipid Signature Predicts Early Rapid Kidney Function Decline in Patients With Type 1 Diabetes

Patients with type 1 diabetes (T1D) exhibit modest lipid abnormalities as measured by traditional metrics. This study aimed to identify lipidomic predictors of rapid decline of kidney function in T1D. In a case-control study, 817 patients with T1D from three large cohorts were randomly split into tr...

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Veröffentlicht in:Diabetes care 2021-09, Vol.44 (9), p.2098-2106
Hauptverfasser: Afshinnia, Farsad, Rajendiran, Thekkelnaycke M, He, Chenchen, Byun, Jaeman, Montemayor, Daniel, Darshi, Manjula, Tumova, Jana, Kim, Jiwan, Limonte, Christine P, Miller, Rachel G, Costacou, Tina, Orchard, Trevor J, Ahluwalia, Tarunveer S, Rossing, Peter, Snell-Bergeon, Janet K, de Boer, Ian H, Natarajan, Loki, Michailidis, George, Sharma, Kumar, Pennathur, Subramaniam
Format: Artikel
Sprache:eng
Schlagworte:
Abnormalities
Abundance
Biomarkers
Carbon
Case-Control Studies
Diabetes
Diabetes mellitus
Diabetes mellitus (insulin dependent)
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Disease Progression
Epidermal growth factor receptors
Fatty acids
Fatty Acids, Nonesterified
Glomerular Filtration Rate
Glycerol
Humans
Kidney
Kidney diseases
Kidneys
Lecithin
Lipids
Mass spectrometry
Mass spectroscopy
Pathophysiology/Complications
Patients
Phosphatidylcholine
Phosphatidylethanolamine
Phospholipids
Renal Insufficiency, Chronic
Risk Factors
Statistical methods
Triglycerides
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Zusammenfassung:Patients with type 1 diabetes (T1D) exhibit modest lipid abnormalities as measured by traditional metrics. This study aimed to identify lipidomic predictors of rapid decline of kidney function in T1D. In a case-control study, 817 patients with T1D from three large cohorts were randomly split into training and validation subsets. Case was defined as >3 mL/min/1.73 m per year decline in estimated glomerular filtration rate (eGFR), while control was defined as
ISSN:0149-5992
1935-5548
DOI:10.2337/dc21-0737