Increased serum cholesterol and long-chain fatty acid levels are associated with the efficacy of nivolumab in patients with non-small cell lung cancer

Background Lipids have immunomodulatory functions and the potential to affect cancer immunity. Methods The associations of pretreatment serum cholesterol and long-chain fatty acids with the objective response rate (ORR), progression-free survival (PFS), and overall survival (OS) were evaluated in 14...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy Immunotherapy, 2022-01, Vol.71 (1), p.203-217
Hauptverfasser:	Karayama, Masato, Inui, Naoki, Inoue, Yusuke, Yoshimura, Katsuhiro, Mori, Kazutaka, Hozumi, Hironao, Suzuki, Yuzo, Furuhashi, Kazuki, Fujisawa, Tomoyuki, Enomoto, Noriyuki, Nakamura, Yutaro, Asada, Kazuhiro, Uto, Tomohiro, Fujii, Masato, Matsui, Takashi, Matsuura, Shun, Hashimoto, Dai, Toyoshima, Mikio, Kusagaya, Hideki, Matsuda, Hiroyuki, Inami, Nao, Kaida, Yusuke, Niwa, Mitsuru, Ito, Yasuhiro, Suda, Takafumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic Agents, Immunological - pharmacology Apoptosis Cancer Research Carcinoma, Non-Small-Cell Lung - blood Carcinoma, Non-Small-Cell Lung - drug therapy Cholesterol Cholesterol - blood Cholesterol, HDL - metabolism Cholesterol, LDL - metabolism Disease-Free Survival Fatty acids Fatty Acids - biosynthesis Female g-linolenic acid Gene Expression Regulation, Neoplastic High density lipoprotein Humans Immune checkpoint inhibitors Immune Checkpoint Inhibitors - metabolism Immunology Immunomodulation Immunotherapy Lauric acid Linoleic acid Linolenic acid Lipids Lipids - chemistry Low density lipoprotein Lung cancer Lung Neoplasms - blood Lung Neoplasms - drug therapy Male Medicine Medicine & Public Health Middle Aged Monoclonal antibodies Nivolumab - pharmacology Non-small cell lung carcinoma Oncology Original Original Article PD-L1 protein Prospective Studies Small cell lung carcinoma Stearic acid Targeted cancer therapy Treatment Outcome
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Zusammenfassung:	Background Lipids have immunomodulatory functions and the potential to affect cancer immunity. Methods The associations of pretreatment serum cholesterol and long-chain fatty acids with the objective response rate (ORR), progression-free survival (PFS), and overall survival (OS) were evaluated in 148 patients with non-small cell lung cancer who received nivolumab. Results When each lipid was separately evaluated, increased low-density lipoprotein (LDL)-cholesterol ( P
ISSN:	0340-7004 1432-0851
DOI:	10.1007/s00262-021-02979-4