mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant

mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant

Recent surveillance has revealed the emergence of the SARS-CoV-2 Omicron variant (BA.1/B.1.1.529) harboring up to 36 mutations in spike protein, the target of neutralizing antibodies. Given its potential to escape vaccine-induced humoral immunity, we measured the neutralization potency of sera from...

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Veröffentlicht in:Cell 2022-02, Vol.185 (3), p.457-466.e4
Hauptverfasser: Garcia-Beltran, Wilfredo F., St. Denis, Kerri J., Hoelzemer, Angelique, Lam, Evan C., Nitido, Adam D., Sheehan, Maegan L., Berrios, Cristhian, Ofoman, Onosereme, Chang, Christina C., Hauser, Blake M., Feldman, Jared, Roederer, Alex L., Gregory, David J., Poznansky, Mark C., Schmidt, Aaron G., Iafrate, A. John, Naranbhai, Vivek, Balazs, Alejandro B.
Format: Artikel
Sprache:eng
Schlagworte:
breadth
COVID-19
Delta
infectivity
neutralizing antibodies
Omicron
SARS-CoV-2
spike
vaccination
variants
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Zusammenfassung:Recent surveillance has revealed the emergence of the SARS-CoV-2 Omicron variant (BA.1/B.1.1.529) harboring up to 36 mutations in spike protein, the target of neutralizing antibodies. Given its potential to escape vaccine-induced humoral immunity, we measured the neutralization potency of sera from 88 mRNA-1273, 111 BNT162b, and 40 Ad26.COV2.S vaccine recipients against wild-type, Delta, and Omicron SARS-CoV-2 pseudoviruses. We included individuals that received their primary series recently (
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2021.12.033