Heated tobacco products for smoking cessation and reducing smoking prevalence

Background Heated tobacco products (HTPs) are designed to heat tobacco to a high enough temperature to release aerosol, without burning it or producing smoke. They differ from e‐cigarettes because they heat tobacco leaf/sheet rather than a liquid. Companies who make HTPs claim they produce fewer har...

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Veröffentlicht in:Cochrane database of systematic reviews 2022-01, Vol.2022 (4), p.CD013790
Hauptverfasser: Brown, Jamie, Tattan-Birch, Harry, Hartmann-Boyce, Jamie, Kock, Loren, Simonavicius, Erikas, Brose, Leonie, Jackson, Sarah, Shahab, Lion
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Sprache:eng
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Zusammenfassung:Background Heated tobacco products (HTPs) are designed to heat tobacco to a high enough temperature to release aerosol, without burning it or producing smoke. They differ from e‐cigarettes because they heat tobacco leaf/sheet rather than a liquid. Companies who make HTPs claim they produce fewer harmful chemicals than conventional cigarettes. Some people report stopping smoking cigarettes entirely by switching to using HTPs, so clinicians need to know whether they are effective for this purpose and relatively safe. Also, to regulate HTPs appropriately, policymakers should understand their impact on health and on cigarette smoking prevalence. Objectives To evaluate the effectiveness and safety of HTPs for smoking cessation and the impact of HTPs on smoking prevalence.  Search methods We searched the Cochrane Tobacco Addiction Group's Specialised Register, CENTRAL, MEDLINE, and six other databases for relevant records to January 2021, together with reference‐checking and contact with study authors and relevant groups. Selection criteria We included randomised controlled trials (RCTs) in which people who smoked cigarettes were randomised to switch to exclusive HTP use or a control condition. Eligible outcomes were smoking cessation, adverse events, and selected biomarkers.  RCTs conducted in clinic or in an ambulatory setting were deemed eligible when assessing safety, including those randomising participants to exclusively use HTPs, smoke cigarettes, or attempt abstinence from all tobacco. Time‐series studies were also eligible for inclusion if they examined the population‐level impact of heated tobacco on smoking prevalence or cigarette sales as an indirect measure. Data collection and analysis We followed standard Cochrane methods for screening and data extraction. Our primary outcome measures were abstinence from smoking at the longest follow‐up point available, adverse events, serious adverse events, and changes in smoking prevalence or cigarette sales. Other outcomes included biomarkers of harm and exposure to toxicants/carcinogens (e.g. NNAL and carboxyhaemoglobin (COHb)). We used a random‐effects Mantel‐Haenszel model to calculate risk ratios (RR) with 95% confidence intervals (CIs) for dichotomous outcomes. For continuous outcomes, we calculated mean differences on the log‐transformed scale (LMD) with 95% CIs. We pooled data across studies using meta‐analysis where possible. Main results We included 13 completed studies, of which 11 were RCTs assessi
ISSN:1465-1858
1469-493X
1465-1858
1469-493X
DOI:10.1002/14651858.CD013790.pub2