Carbon dioxide redox metabolites in oxidative eustress and oxidative distress

High carbon dioxide tensions (hypercapnia) are toxic to mammals by both pH-dependent and pH-independent mechanisms that remain partially understood. Relevantly, carbon dioxide reacts with biologically ubiquitous oxygen metabolites such as peroxynitrite and hydrogen peroxide to produce carbonate radi...

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Veröffentlicht in:	Biophysical reviews 2021-12, Vol.13 (6), p.889-891
Hauptverfasser:	Augusto, Ohara, Truzzi, Daniela Ramos
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological and Medical Physics Biological Techniques Biomedical and Life Sciences Biophysics Carbon dioxide Cell Biology Hydrogen peroxide Hypercapnia Letter to the Editor Life Sciences Membrane Biology Metabolites Nanotechnology Peroxynitrite pH effects
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Beschreibung
Zusammenfassung:	High carbon dioxide tensions (hypercapnia) are toxic to mammals by both pH-dependent and pH-independent mechanisms that remain partially understood. Relevantly, carbon dioxide reacts with biologically ubiquitous oxygen metabolites such as peroxynitrite and hydrogen peroxide to produce carbonate radical and peroxymonocarbonate, respectively. These metabolites are redox active making it timely to discuss the potential role of carbon dioxide redox metabolites in oxidative eustress and oxidative distress conditions.
ISSN:	1867-2450 1867-2469
DOI:	10.1007/s12551-021-00860-3