Kim-1 Targeted Extracellular Vesicles: A New Therapeutic Platform for RNAi to Treat AKI

AKI is a significant public health problem with high morbidity and mortality. Unfortunately, no definitive treatment is available for AKI. RNA interference (RNAi) provides a new and potent method for gene therapy to tackle this issue. We engineered red blood cell-derived extracellular vesicles (REVs...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2021-10, Vol.32 (10), p.2467-2483
Hauptverfasser:	Tang, Tao-Tao, Wang, Bin, Li, Zuo-Lin, Wen, Yi, Feng, Song-Tao, Wu, Min, Liu, Dan, Cao, Jing-Yuan, Yin, Qing, Yin, Di, Fu, Yu-Qi, Gao, Yue-Ming, Ding, Zhao-Ying, Qian, Jing-Yi, Wu, Qiu-Li, Lv, Lin-Li, Liu, Bi-Cheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - pathology Acute Kidney Injury - therapy Animals Basic Research Disease Models, Animal Erythrocytes Extracellular Vesicles Fibrosis Genetic Therapy - methods Hepatitis A Virus Cellular Receptor 1 - genetics Inflammation - therapy Kidney Tubules - metabolism Kidney Tubules - pathology Male Mice Peptides Reperfusion Injury - complications RNA Interference RNA, Small Interfering - therapeutic use Snail Family Transcription Factors - genetics Snail Family Transcription Factors - metabolism Transcription Factor RelA - genetics Transcription Factor RelA - metabolism Ureteral Obstruction - complications
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