Aberrant GIMAP2 expression affects oral squamous cell carcinoma progression by promoting cell cycle and inhibiting apoptosis

GTPases of immunity-associated protein 2 (GIMAP2) is a GTPase family member associated with T cell survival. However, its mechanisms of action in oral squamous cell carcinoma (OSCC) remain largely unknown. Therefore, the present study aimed to elucidate the possible role of GIMAP2 in OSCC developmen...

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Veröffentlicht in:	Oncology letters 2022-02, Vol.23 (2), p.49, Article 49
Hauptverfasser:	Komatsu, Mari, Saito, Kengo, Miyamoto, Isao, Koike, Kazuyuki, Iyoda, Manabu, Nakashima, Dai, Kasamatsu, Atsushi, Shiiba, Masashi, Tanzawa, Hideki, Uzawa, Katsuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biotechnology Biotechnology industry Cell cycle Comparative analysis Cyclin-dependent kinases G proteins Immunohistochemistry Instrument industry Kinases Laboratories Leukemia Lymphocytes Membranes Monoclonal antibodies Oncology Oral cancer Polyclonal antibodies Proteins Squamous cell carcinoma T cells Tongue Tumor proteins
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Zusammenfassung:	GTPases of immunity-associated protein 2 (GIMAP2) is a GTPase family member associated with T cell survival. However, its mechanisms of action in oral squamous cell carcinoma (OSCC) remain largely unknown. Therefore, the present study aimed to elucidate the possible role of GIMAP2 in OSCC development by investigating its expression levels and molecular mechanisms in OSCC. Reverse transcription quantitative PCR, immunoblotting and immunohistochemistry indicated that GIMAP2 expression was significantly upregulated (P
ISSN:	1792-1074 1792-1082
DOI:	10.3892/ol.2021.13167