Thank ORP9 for FFAT: With endosomal ORP10, it's fission accomplished

Thank ORP9 for FFAT: With endosomal ORP10, it's fission accomplished

Heterogeneity in endosomal membrane phospholipid content is emerging as a regulator of endocytic trafficking pathways. Kawasaki et al. (2021. J. Cell. Biol.https://doi.org/10.1083/jcb.202103141) demonstrate exchange of endosomal PI4P for PS by ORP10 at ER-endosome contact sites, with the consequent...

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Veröffentlicht in:The Journal of cell biology 2022-01, Vol.221 (1)
Hauptverfasser: Wong, Louise H, Martello, Andrea, Eden, Emily R
Format: Artikel
Sprache:eng
Schlagworte:
Endosomes
Mitochondrial Membranes
Ophthalmology
Spotlight
University colleges
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Zusammenfassung:Heterogeneity in endosomal membrane phospholipid content is emerging as a regulator of endocytic trafficking pathways. Kawasaki et al. (2021. J. Cell. Biol.https://doi.org/10.1083/jcb.202103141) demonstrate exchange of endosomal PI4P for PS by ORP10 at ER-endosome contact sites, with the consequent recruitment of endosomal fission factors.
ISSN:0021-9525
1540-8140
1540-8140
DOI:10.1083/jcb.202112057