An epigenetic aging analysis of randomized metformin and weight loss interventions in overweight postmenopausal breast cancer survivors

Metformin and weight loss relationships with epigenetic age measures-biological aging biomarkers-remain understudied. We performed a post-hoc analysis of a randomized controlled trial among overweight/obese breast cancer survivors (N = 192) assigned to metformin, placebo, weight loss with metformin,...

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Veröffentlicht in:	Clinical epigenetics 2021-12, Vol.13 (1), p.224, Article 224
Hauptverfasser:	Nwanaji-Enwerem, Jamaji C, Chung, Felicia Fei-Lei, Van der Laan, Lars, Novoloaca, Alexei, Cuenin, Cyrille, Johansson, Harriet, Bonanni, Bernardo, Hubbard, Alan E, Smith, Martyn T, Hartman, Sheri J, Cardenas, Andres, Sears, Dorothy D, Herceg, Zdenko
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Aging Aging - genetics Aging - physiology Analysis Biomarkers Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Body weight Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - physiopathology Cancer survivors Care and treatment Diabetes therapy DNA methylation Epigenetic inheritance Epigenetics Female Humans Intervention Metformin Metformin - administration & dosage Metformin - pharmacology Methylation Middle Aged Mortality Overweight Overweight - epidemiology Overweight - therapy Placebos Post-menopause Postmenopausal women Postmenopause Quality control Short Report Survivors - statistics & numerical data Trends Weight loss Weight Reduction Programs - methods Weight Reduction Programs - standards Weight Reduction Programs - statistics & numerical data
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Zusammenfassung:	Metformin and weight loss relationships with epigenetic age measures-biological aging biomarkers-remain understudied. We performed a post-hoc analysis of a randomized controlled trial among overweight/obese breast cancer survivors (N = 192) assigned to metformin, placebo, weight loss with metformin, or weight loss with placebo interventions for 6 months. Epigenetic age was correlated with chronological age (r = 0.20-0.86; P
ISSN:	1868-7075 1868-7083 1868-7083 1868-7075
DOI:	10.1186/s13148-021-01218-y