Cohort study of Covid-19 vaccine effectiveness among healthcare workers in Finland, December 2020 - October 2021

Recently, Covid-19 vaccine effectiveness has decreased especially against mild disease due to emergence of the Delta variant and waning protection. In this register-based study among healthcare workers in Finland, the vaccine effectiveness of two-dose mRNA vaccine series against SARS-CoV-2 infection...

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Veröffentlicht in:	Vaccine 2022-01, Vol.40 (5), p.701-705
Hauptverfasser:	Poukka, Eero, Baum, Ulrike, Palmu, Arto A., Lehtonen, Toni O., Salo, Heini, Nohynek, Hanna, Leino, Tuija
Format:	Artikel
Sprache:	eng
Schlagworte:	BNT162 Vaccine Cohort analysis Cohort Studies Coronaviruses COVID-19 Covid-19 hospitalization COVID-19 Vaccines Decision making Disease transmission Drug dosages Finland - epidemiology Funding Health care Health Personnel Healthcare workers Hospitalization Humans Infections Laboratories Medical personnel mRNA mRNA Vaccines SARS-CoV-2 SARS-CoV-2 infection Severe acute respiratory syndrome coronavirus 2 Short Communication Vaccination Vaccine effectiveness Vaccine Efficacy Vaccines Vaccines, Synthetic Viral diseases Waning
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Beschreibung
Zusammenfassung:	Recently, Covid-19 vaccine effectiveness has decreased especially against mild disease due to emergence of the Delta variant and waning protection. In this register-based study among healthcare workers in Finland, the vaccine effectiveness of two-dose mRNA vaccine series against SARS-CoV-2 infection decreased from 82% (95% CI 79–85%) 14–90 days after vaccination to 53% (43–62%) after 6 months. Similar trend was observed for other series. Waning was not observed against Covid-19 hospitalization. These results facilitate decision-making of booster doses for healthcare workers.
ISSN:	0264-410X 1873-2518 1873-2518
DOI:	10.1016/j.vaccine.2021.12.032