Aliskiren Alone or in Combination With Hydrochlorothiazide in Patients With the Lower Ranges of Stage 2 Hypertension: The ACQUIRE Randomized Double‐Blind Study

J Clin Hypertens (Greenwich). © 2010 Wiley Periodicals, Inc. Patients with stage 2 hypertension (systolic blood pressure [SBP] ≥160 mm Hg and/or diastolic blood pressure [DBP] ≥100 mm Hg) are at high cardiovascular risk and require intensive blood pressure (BP)–lowering therapy. This randomized double‐blind study is the first prospective trial specifically designed to evaluate the direct renin inhibitor aliskiren in patients with a mean sitting SBP ≥160 mm Hg and