Recent advances in drug repurposing using machine learning

Drug repurposing aims to find new uses for already existing and approved drugs. We now provide a brief overview of recent developments in drug repurposing using machine learning alongside other computational approaches for comparison. We also highlight several applications for cancer using kinase inhibitors, Alzheimer’s disease as well as COVID-19. [Display omitted] •Machine learning for drug repurposing was increasing before 2020.•It has been applied to model small molecule screening data, transcriptomics and proteomics.•Computationally repurposed approved kinase inhibitors have been identified by several groups.•Computational repurposing can be used in areas of difficult drug discovery e.g. antibiotics and Alzheimer 's disease.