IFT trains overcome an NPHP module barrier at the transition zone

IFT trains overcome an NPHP module barrier at the transition zone

Cilia harbor diffusion barriers for soluble and membrane proteins within their proximal-most transition zone (TZ) region and employ an intraflagellar transport (IFT) system to form dynamic motile and signaling compartments. In this issue, De-Castro and colleagues (2021. J. Cell Biol.https://doi.org/...

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Veröffentlicht in:The Journal of cell biology 2022-01, Vol.221 (1)
Hauptverfasser: Park, Kwangjin, Leroux, Michel R
Format: Artikel
Sprache:eng
Schlagworte:
Biological Transport
Cilia
Cilia - metabolism
Diffusion
Genetics
Membrane Proteins - genetics
Membrane Proteins - metabolism
Signal Transduction
Spotlight
Transition zone
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Beschreibung
Zusammenfassung:Cilia harbor diffusion barriers for soluble and membrane proteins within their proximal-most transition zone (TZ) region and employ an intraflagellar transport (IFT) system to form dynamic motile and signaling compartments. In this issue, De-Castro and colleagues (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202010178) uncover a long-suspected role for the TZ in gating IFT particles.
ISSN:0021-9525
1540-8140
1540-8140
DOI:10.1083/jcb.202112015