ENDOCRINE DISTURBANCES INDUCED BY LOW-DOSE ORGANOPHOSPHATE EXPOSURE IN MALE WISTAR RATS

ENDOCRINE DISTURBANCES INDUCED BY LOW-DOSE ORGANOPHOSPHATE EXPOSURE IN MALE WISTAR RATS

Organophosphate exposure induces many endocrine effects. In this study we observed the effects of acute stress induced by cholinesterase inhibition on the main hormonal axes. We included thirteen weanling Wistar rats that were subjected to organophosphate exposure. They were first tested for baselin...

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Veröffentlicht in:Acta endocrinologica (Bucharest, Romania : 2005) Romania : 2005), 2021-04, Vol.17 (2), p.177-185
Hauptverfasser: Cobilinschi, C, Tincu, R C, Băetu, A E, Deaconu, C O, Totan, A, Rusu, A, Neagu, P T, Grințescu, I M
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Sprache:eng
Schlagworte:
General Endocrinology
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Zusammenfassung:Organophosphate exposure induces many endocrine effects. In this study we observed the effects of acute stress induced by cholinesterase inhibition on the main hormonal axes. We included thirteen weanling Wistar rats that were subjected to organophosphate exposure. They were first tested for baseline levels of butyrylcholinesterase, cortisol, free triiodothyronine, thyroxine, thyroid-stimulating hormone and prolactin. Secondly, chlorpyrifos was administered. Next samples were taken to determine the level of all the above-mentioned parameters. Butyrylcholinesterase was significantly decreased after exposure (p
ISSN:1841-0987
1843-066X
DOI:10.4183/aeb.2021.177