Neuroserpin and transthyretin are extracellular chaperones that preferentially inhibit amyloid formation

Neuroserpin is a secreted protease inhibitor known to inhibit amyloid formation by the Alzheimer’s beta peptide (Aβ). To test whether this effect was constrained to Aβ, we used a range of in vitro assays to demonstrate that neuroserpin inhibits amyloid formation by several different proteins and pro...

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Veröffentlicht in:	Science advances 2021-12, Vol.7 (50), p.eabf7606-eabf7606
Hauptverfasser:	West, Jennifer, Satapathy, Sandeep, Whiten, Daniel R, Kelly, Megan, Geraghty, Nicholas J, Proctor, Emma-Jayne, Sormanni, Pietro, Vendruscolo, Michele, Buxbaum, Joel N, Ranson, Marie, Wilson, Mark R
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedicine and Life Sciences Cell Biology SciAdv r-articles
Online-Zugang:	Volltext
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