Performance comparison of micro-neutralization assays based on surrogate SARS-CoV-2 and WT SARS-CoV-2 in assessing virus-neutralizing capacity of anti-SARS-CoV-2 antibodies

Performance comparison of micro-neutralization assays based on surrogate SARS-CoV-2 and WT SARS-CoV-2 in assessing virus-neutralizing capacity of anti-SARS-CoV-2 antibodies

We compared neutralization assays using either the wild-type severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus or surrogate neutralization markers, using characterized sera. We found the results of the neutralization assays 75 % concordant overall and 80 % concordant for samples wit...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Access microbiology 2021-08, Vol.3 (8), p.000257-000257
Hauptverfasser: Sekirov, Inna, Petric, Martin, Carruthers, Erin, Lawrence, David, Pidduck, Tamara, Kustra, Jesse, Laley, Jonathan, Lee, Min-Kuang, Chahil, Navdeep, Mak, Annie, Levett, Paul N., Mendoza, Emelissa, Wood, Heidi, Drebot, Mike, Krajden, Mel, Morshed, Muhammad
Format: Artikel
Sprache:eng
Schlagworte:
Short Communications
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:We compared neutralization assays using either the wild-type severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus or surrogate neutralization markers, using characterized sera. We found the results of the neutralization assays 75 % concordant overall and 80 % concordant for samples with high antibody levels. This demonstrates that commercial surrogate SARS-CoV-2 assays offer the potential to assess anti-SARS-CoV-2 antibodies’ neutralizing capacity outside CL-3 laboratory containment.
ISSN:2516-8290
2516-8290
DOI:10.1099/acmi.0.000257