Underserved population acceptance of combination influenza-COVID-19 booster vaccines

•Public acceptance of COVID-19 vaccines and booster is low.•“COVID fatigue” appears to be driving intended receipt of COVID-19 boosters lower.•Minorities are receptive to receive a combination influenza-COVID-19-booster.•Bundling novel with accepted vaccines may improve coverage among minorities. Recent data indicates increasing hesitancy towards both COVID-19 and influenza vaccination. We studied attitudes towards COVID-19 booster, influenza, and combination influenza-COVID-19 booster vaccines in a nationally representative sample of US adults between May and June 2021 (n = 12,887). We used pre-qualification quotes to ensure adequate sample sizes for minority populations. Overall vaccine acceptance was 45% for a COVID-19 booster alone, 58% for an influenza vaccine alone, and 50% for a combination vaccine. Logistic regression showed lower acceptance among female, Black/African American, Native American/American Indian, and rural respondents. Higher acceptance was found among those with college and post-graduate degrees. Despite these differences, our results suggest that a combination vaccine may provide a convenient method of dual vaccination that may increase COVID-19 vaccination coverage.