The prognostic value of TCF1+CD8+T in primary small cell carcinoma of the esophagus

TCF1+CD8+T cells are reported to exhibit stem‐like properties with the ability to self‐renew and differentiate into terminal effector T cells (TCF1‐CD8+T cells) to enhance antitumor response. Previous studies indicated that TCF1+CD8+ tumor‐infiltrating lymphocytes (TILs) are related to response to i...

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Veröffentlicht in:	Cancer science 2021-12, Vol.112 (12), p.4968-4976
Hauptverfasser:	Ma, Lin, Sun, Lijun, Zhao, Kaikai, Dong, Zhengxin, Huang, Zhaoqin, Meng, Xiangjiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antigens Antitumor activity Cancer therapies Carcinoma, Small Cell - metabolism Carcinoma, Small Cell - pathology CD4-CD8 Ratio CD8 antigen CD8-Positive T-Lymphocytes - metabolism Cell differentiation Chemotherapy Effector cells Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophagus Female Fluorescent Antibody Technique Hepatocyte nuclear factor 1 Hepatocyte Nuclear Factor 1-alpha - metabolism Humans Immunohistochemistry Immunotherapy Infiltration Lymphocytes Lymphocytes T Lymphocytes, Tumor-Infiltrating - metabolism Male Medical prognosis Metastases Multivariate analysis Original Patients Prognosis PSCCE Software stem‐like Survival Analysis TCF1 Transcription factors Tumor Microenvironment
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Zusammenfassung:	TCF1+CD8+T cells are reported to exhibit stem‐like properties with the ability to self‐renew and differentiate into terminal effector T cells (TCF1‐CD8+T cells) to enhance antitumor response. Previous studies indicated that TCF1+CD8+ tumor‐infiltrating lymphocytes (TILs) are related to response to immunotherapy. However, their role in predicting prognosis for patients with primary small cell carcinoma of the esophagus (PSCCE) remains unclear. In this study, the expression of TCF1+CD8+T was analyzed by multiplex fluorescence immunohistochemistry in tumor tissues of 79 patients with PSCCE. High infiltration of TCF1+CD8+T cells had longer overall survival (OS) than low infiltration (P = .009, hazard ratio [HR] = 0.506). High TCF1+CD8/CD8 ratio (>21%) showed superior OS compared with low ratio (≤21%) (P
ISSN:	1347-9032 1349-7006
DOI:	10.1111/cas.15167