Ragulator-Rag and ROS TORment gasdermin D pore formation

Upon cleavage, the Gasdermin D (GSDMD) N-terminal fragment assembles into pores on the plasma membrane to orchestrate the lytic cell death known as pyroptosis. In a recent article, Evavold et al. showed that the Ragulator-Rag-mTORC1-ROS pathway controls the transition from cleavage and membrane loca...

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Veröffentlicht in:	Trends in immunology 2021-11, Vol.42 (11), p.948-950
Hauptverfasser:	Magupalli, Venkat Giri, Fontana, Pietro, Wu, Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cell death Cleavage Ductile-brittle transition Humans Inflammasomes - metabolism Intracellular Signaling Peptides and Proteins - metabolism Localization Membranes Neoplasm Proteins - metabolism Oligomerization Phosphate-Binding Proteins Plasma Pore formation Pyroptosis Reactive Oxygen Species - metabolism
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Beschreibung
Zusammenfassung:	Upon cleavage, the Gasdermin D (GSDMD) N-terminal fragment assembles into pores on the plasma membrane to orchestrate the lytic cell death known as pyroptosis. In a recent article, Evavold et al. showed that the Ragulator-Rag-mTORC1-ROS pathway controls the transition from cleavage and membrane localization to oligomerization and pore formation.
ISSN:	1471-4906 1471-4981
DOI:	10.1016/j.it.2021.09.014