The associations between Deltex1 and clinical characteristics of breast cancer

Deltex 1 ( ) is a single transmembrane protein with ubiquitin E3 ligase activity which has been found to play a role in the development of several cancers. We aimed to investigate the associations between and breast cancer (BC). We explored the roles and mechanisms of in BC by using BC cell lines . Levels of in serum and tissues were determined in 316 patients with BC, 102 patients with fibroadenoma, and 113 healthy controls by immunohistochemistry (IHC) and reverse transcription-polymerase chain reaction (RT-PCR). The associations between and clinical characteristics of BC were analyzed using multivariate analysis and Cox regression survival analysis. Lower levels of promoted BC cell proliferation, migration, and invasion. The cell growth and survival of BC might be regulated by DTX1 via the Notch signaling pathway. Levels of in BC tissues were lower compared to fibroadenoma tissues and peri-neoplastic breast tissues (P