Urinary Beta-2-Microglobulin and Late Nephrotoxicity in Childhood Cancer Survivors

Urinary Beta-2-Microglobulin and Late Nephrotoxicity in Childhood Cancer Survivors

The objectives of this study were to evaluate urinary beta-2-microglobulin (β2M) levels in long-term childhood cancer survivors and to establish its association with anticancer drug-induced nephrotoxicity. The study consisted of 165 childhood cancer survivors (CCS) who were in continuous complete re...

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Veröffentlicht in:Journal of clinical medicine 2021-11, Vol.10 (22), p.5279
Hauptverfasser: Latoch, Eryk, Konończuk, Katarzyna, Taranta-Janusz, Katarzyna, Muszyńska-Rosłan, Katarzyna, Sawicka, Magdalena, Wasilewska, Anna, Krawczuk-Rybak, Maryna
Format: Artikel
Sprache:eng
Schlagworte:
Abdomen
Biomarkers
Blood pressure
Cancer therapies
Childhood
Clinical medicine
Creatinine
Females
Hypertension
Kidney diseases
Normal distribution
Pediatrics
Radiation therapy
Statistical analysis
Urine
Urogenital system
Variance analysis
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Zusammenfassung:The objectives of this study were to evaluate urinary beta-2-microglobulin (β2M) levels in long-term childhood cancer survivors and to establish its association with anticancer drug-induced nephrotoxicity. The study consisted of 165 childhood cancer survivors (CCS) who were in continuous complete remission. We reported that CCS had a significantly higher level of β2M (p < 0.001) and β2M/Cr. ratio (p < 0.05) than healthy peers. Among all participants, 24 (14.5%) had decreased eGFR (
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm10225279