Production and Supply of α-Particle-Emitting Radionuclides for Targeted α-Therapy

Encouraging results from targeted α-therapy have received significant attention from academia and industry. However, the limited availability of suitable radionuclides has hampered widespread translation and application. In the present review, we discuss the most promising candidates for clinical ap...

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Veröffentlicht in:	Journal of Nuclear Medicine 2021-11, Vol.62 (11), p.1495-1503
Hauptverfasser:	Radchenko, Valery, Morgenstern, Alfred, Jalilian, Amir R, Ramogida, Caterina F, Cutler, Cathy, Duchemin, Charlotte, Hoehr, Cornelia, Haddad, Ferrid, Bruchertseifer, Frank, Gausemel, Haavar, Yang, Hua, Osso, Joao Alberto, Washiyama, Kohshin, Czerwinski, Kenneth, Leufgen, Kirsten, Pruszyński, Marek, Valzdorf, Olga, Causey, Patrick, Schaffer, Paul, Perron, Randy, Maxim, Samsonov, Wilbur, D Scott, Stora, Thierry, Li, Yawen
Format:	Artikel
Sprache:	eng
Schlagworte:	Alpha Particles - therapeutic use Chelation Humans Nuclear medicine Radioisotopes Radioisotopes - chemistry Radioisotopes - therapeutic use Radiopharmaceuticals - therapeutic use The State of the Art
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Beschreibung
Zusammenfassung:	Encouraging results from targeted α-therapy have received significant attention from academia and industry. However, the limited availability of suitable radionuclides has hampered widespread translation and application. In the present review, we discuss the most promising candidates for clinical application and the state of the art of their production and supply. In this review, along with 2 forthcoming reviews on chelation and clinical application of α-emitting radionuclides, will provide a comprehensive assessment of the field.
ISSN:	0161-5505 1535-5667 1535-5667 2159-662X
DOI:	10.2967/jnumed.120.261016