LIM domain proteins in cell mechanobiology
The actin cytoskeleton is important for maintaining mechanical homeostasis in adherent cells, largely through its regulation of adhesion and cortical tension. The LIM (Lin‐11, Isl1, MEC‐3) domain‐containing proteins are involved in a myriad of cellular mechanosensitive pathways. Recent work has disc...
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| Veröffentlicht in: | Cytoskeleton (Hoboken, N.J.) N.J.), 2021-06, Vol.78 (6), p.303-311 |
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| container_title | Cytoskeleton (Hoboken, N.J.) |
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| creator | Anderson, Caitlin A. Kovar, David R. Gardel, Margaret L. Winkelman, Jonathan D. |
| description | The actin cytoskeleton is important for maintaining mechanical homeostasis in adherent cells, largely through its regulation of adhesion and cortical tension. The LIM (Lin‐11, Isl1, MEC‐3) domain‐containing proteins are involved in a myriad of cellular mechanosensitive pathways. Recent work has discovered that LIM domains bind to mechanically stressed actin filaments, suggesting a novel and widely conserved mechanism of mechanosensing. This review summarizes the current state of knowledge of LIM protein mechanosensitivity. |
| doi_str_mv | 10.1002/cm.21677 |
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The LIM (Lin‐11, Isl1, MEC‐3) domain‐containing proteins are involved in a myriad of cellular mechanosensitive pathways. Recent work has discovered that LIM domains bind to mechanically stressed actin filaments, suggesting a novel and widely conserved mechanism of mechanosensing. 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The LIM (Lin‐11, Isl1, MEC‐3) domain‐containing proteins are involved in a myriad of cellular mechanosensitive pathways. Recent work has discovered that LIM domains bind to mechanically stressed actin filaments, suggesting a novel and widely conserved mechanism of mechanosensing. This review summarizes the current state of knowledge of LIM protein mechanosensitivity.</description><subject>Actin</subject><subject>actin cytoskeleton</subject><subject>Actin Cytoskeleton - metabolism</subject><subject>Actins - metabolism</subject><subject>adherens junctions</subject><subject>Adherent cells</subject><subject>Biophysics</subject><subject>Cell Communication</subject><subject>Cytoskeleton</subject><subject>Filaments</subject><subject>focal adhesions</subject><subject>Homeostasis</subject><subject>Islet-1 protein</subject><subject>LIM domain proteins</subject><subject>LIM Domain Proteins - genetics</subject><subject>LIM Domain Proteins - metabolism</subject><subject>LIM protein</subject><subject>LIM proteins</subject><subject>Protein Binding</subject><issn>1949-3584</issn><issn>1949-3592</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kdtKAzEQhoMotlbBJ5CCNyKs5tRkcyNI8VBo8UavQzabtCm7m5p0lb69qa31AF5lIB_fzD8DwCmCVwhCfK3rK4wY53ugiwQVGRkIvL-rc9oBRzHOIWSCQHIIOoRCnCMhuuByPJr0S18r1_QXwS-Na2I_1dpUVb82eqYaXzhf-enqGBxYVUVzsn174OX-7nn4mI2fHkbD23GmKcl5ZjnHtoSaG0iFUVYgWqReWjCmLTJMQ2ZzrjFVFgtbaK0TbAyiJdXMUEF64GbjXbRFbUptmmVQlVwEV6uwkl45-funcTM59W8yZzAF40lwsRUE_9qauJS1i-tAqjG-jRIPCBoQihFJ6PkfdO7b0KR4ieI5JwTm7Fuog48xGLsbBkG5PoDUtfw8QELPfg6_A782noBsA7y7yqz-FcnhZCP8AKMhji8</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Anderson, Caitlin A.</creator><creator>Kovar, David R.</creator><creator>Gardel, Margaret L.</creator><creator>Winkelman, Jonathan D.</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1846-9854</orcidid></search><sort><creationdate>202106</creationdate><title>LIM domain proteins in cell mechanobiology</title><author>Anderson, Caitlin A. ; Kovar, David R. ; Gardel, Margaret L. ; Winkelman, Jonathan D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4387-f772fd0c7e049eaf914b819c966cf1e6c06f87c24af29fbcccd0cee14d4c6e493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Actin</topic><topic>actin cytoskeleton</topic><topic>Actin Cytoskeleton - metabolism</topic><topic>Actins - metabolism</topic><topic>adherens junctions</topic><topic>Adherent cells</topic><topic>Biophysics</topic><topic>Cell Communication</topic><topic>Cytoskeleton</topic><topic>Filaments</topic><topic>focal adhesions</topic><topic>Homeostasis</topic><topic>Islet-1 protein</topic><topic>LIM domain proteins</topic><topic>LIM Domain Proteins - genetics</topic><topic>LIM Domain Proteins - metabolism</topic><topic>LIM protein</topic><topic>LIM proteins</topic><topic>Protein Binding</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anderson, Caitlin A.</creatorcontrib><creatorcontrib>Kovar, David R.</creatorcontrib><creatorcontrib>Gardel, Margaret L.</creatorcontrib><creatorcontrib>Winkelman, Jonathan D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cytoskeleton (Hoboken, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anderson, Caitlin A.</au><au>Kovar, David R.</au><au>Gardel, Margaret L.</au><au>Winkelman, Jonathan D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>LIM domain proteins in cell mechanobiology</atitle><jtitle>Cytoskeleton (Hoboken, N.J.)</jtitle><addtitle>Cytoskeleton (Hoboken)</addtitle><date>2021-06</date><risdate>2021</risdate><volume>78</volume><issue>6</issue><spage>303</spage><epage>311</epage><pages>303-311</pages><issn>1949-3584</issn><eissn>1949-3592</eissn><abstract>The actin cytoskeleton is important for maintaining mechanical homeostasis in adherent cells, largely through its regulation of adhesion and cortical tension. 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| identifier | ISSN: 1949-3584 |
| ispartof | Cytoskeleton (Hoboken, N.J.), 2021-06, Vol.78 (6), p.303-311 |
| issn | 1949-3584 1949-3592 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Actin actin cytoskeleton Actin Cytoskeleton - metabolism Actins - metabolism adherens junctions Adherent cells Biophysics Cell Communication Cytoskeleton Filaments focal adhesions Homeostasis Islet-1 protein LIM domain proteins LIM Domain Proteins - genetics LIM Domain Proteins - metabolism LIM protein LIM proteins Protein Binding |
| title | LIM domain proteins in cell mechanobiology |
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