LIM domain proteins in cell mechanobiology

LIM domain proteins in cell mechanobiology

The actin cytoskeleton is important for maintaining mechanical homeostasis in adherent cells, largely through its regulation of adhesion and cortical tension. The LIM (Lin‐11, Isl1, MEC‐3) domain‐containing proteins are involved in a myriad of cellular mechanosensitive pathways. Recent work has disc...

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Veröffentlicht in:Cytoskeleton (Hoboken, N.J.) N.J.), 2021-06, Vol.78 (6), p.303-311
Hauptverfasser: Anderson, Caitlin A., Kovar, David R., Gardel, Margaret L., Winkelman, Jonathan D.
Format: Artikel
Sprache:eng
Schlagworte:
Actin
actin cytoskeleton
Actin Cytoskeleton - metabolism
Actins - metabolism
adherens junctions
Adherent cells
Biophysics
Cell Communication
Cytoskeleton
Filaments
focal adhesions
Homeostasis
Islet-1 protein
LIM domain proteins
LIM Domain Proteins - genetics
LIM Domain Proteins - metabolism
LIM protein
LIM proteins
Protein Binding
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Zusammenfassung:The actin cytoskeleton is important for maintaining mechanical homeostasis in adherent cells, largely through its regulation of adhesion and cortical tension. The LIM (Lin‐11, Isl1, MEC‐3) domain‐containing proteins are involved in a myriad of cellular mechanosensitive pathways. Recent work has discovered that LIM domains bind to mechanically stressed actin filaments, suggesting a novel and widely conserved mechanism of mechanosensing. This review summarizes the current state of knowledge of LIM protein mechanosensitivity.
ISSN:1949-3584
1949-3592
DOI:10.1002/cm.21677